The memorandum of understanding with UK Research and Innovation (UKRI) includes the Biotechnology and Biological Sciences Research Council (BBSRC), with priority to applications in the area of food security and/ or Bioenergy and Industrial Biotechnology.
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The diversity of functions performed by the nervous system depends on the variety of cells that make it up and their specific connectivity patterns for information processing. The vertebrate retina is formed by an organized neural network that is highly conserved in vertebrates, with five classes of neurons. However, specific types of cells within each class of neurons and their signal tr…
Background: Somatic hypermutation (SHM) of immunoglobulin variable (V) regions in B cells is the molecular basis for the diversification of antibodies in response to pathogens and vaccines and, therefore, for robust long-term humoral immunity. Mutations are generated by activation-induced cytidine deaminase (AID) which converts cytosines to uracils preferentially at WRCH motifs (where W =…
Mitochondria are the main source of energy within cells. They are made from over ~1100 proteins which are coded by two different genomes: nuclear DNA and mitochondrial DNA (mtDNA). MtDNA is only inherited from our mother, and codes for 13 mitochondrial proteins that are essential for cell energy production. In humans, mtDNA varies considerably between different people (called mtDNA single…
(Only some records are available in English at this moment)
Our work has shown that an allosteric relationship exists between circulatory non-esterified fatty acid (NEFA) transport and plasma zinc handling through binding to human serum albumin (HSA). This suggests that plasma zinc speciation is influenced by NEFAs in disease states in a manner that impacts upon circulatory processes, including coagulation and insulin signalling. We will examine h…
Invasive crop pests are a major challenge of our times, and lead to huge economic costs to agriculture. One less well recognised aspect of such invasions is that invasive species often hybridise with related native species. This can have various potential outcomes: One possibility is that hybridisation leads to a collapse of the species barrier and a single mixed population. Alternatively…
Toxoplasma gondii is an important zoonotic parasite with global impact capable of infecting all warm-blooded animals. Toxoplasmosis is recognised by the World Health Organisation as one of the most important foodborne diseases worldwide and is also a major cause of production loss in sheep.Research into its genetic diversity has revealed an abundance of atypical strains in South America w…
(Only some records are available in English at this moment)
Mitochondria are the principal source of cellular energy which is produced by oxidative phosphorylation (OXPHOS) leading to the production of adenosine triphosphate (ATP). Thirteen essential OXPHOS proteins are synthesised within the mitochondrion from mitochondrial DNA (mtDNA) which is exclusively inherited down the maternal line. MtDNA is highly polymorphic in humans, but the single nuc…
Mitochondria are the principal source of cellular energy which is produced by oxidative phosphorylation (OXPHOS) leading to the production of adenosine triphosphate (ATP). Thirteen essential OXPHOS proteins are synthesised within the mitochondrion from mitochondrial DNA (mtDNA) which is exclusively inherited down the maternal line. MtDNA is highly polymorphic in humans, but the single nuc…
Plants rely on sophisticated molecular pathways to regulate the rate of energy accumulation and consumption. One form of energy storage is starch, a glucose polymer that allows for maintaining the necessary energy balance for robust growth during the night period when photosynthesis is inactive. Thus, it can be noted how controlling starch degradation in response to environmental stimuli …
(Only some records are available in English at this moment)
The efficient management of energy resources is crucial for plants to integrate their growth with the constant changes in the environment. Sugars derived from CO2 fixation through photosynthesis represent the primary source of energy. These sugars are partitioned between sucrose and starch (a glucose polymer), consumed during the nighttime to sustain growth. In Arabidopsis thaliana, starc…
(Only some records are available in English at this moment)
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