University of Cambridge

The agreement with the University of Cambridge aims at implementing scientific and technological cooperation between researchers of the University and researchers of Higher Education and Research Institutions of the State of São Paulo, Brazil, through the funding of joint research projects. Agreement available from 2013 to 2016.

FAPESP Cooperation Partnerships and Agreements

Research grants

Completed (most recent)

Abstract
Aminoglycosides are antibiotcs which have a core moiety and various unusual sugars, such as aminosugars and desoxysugars that together with their functional groups are essential for its antibiotic activity, which is the inhibition of protein synthesis due to the interaction with the 305 subunit of bacterial ribosome. Although their toxic effects, aminoglicoside antibiotics are largely pre…
Towards safer aminogrycoside antibiotics: structure, function and engineering studies of key biosynthetic enzymes, AP.R
Abstract
The circadian clock is a signalling pathway that encodes temporal information. This pathway allows the metabolism and physiology of plants to be synchronized to rhythmic environmental changes, which increases biomass accumulation. Recently, a new pathway in the circadian clock in which photosynthetically-derived sugars regulate the clock through a "metabolic-dawn" has been described. In a…
Circardian and sugar signalling in grasses, AP.BIOEN.R
Abstract
It is estimated that thousands of long non-coding RNAs (IncRNAs) are transcribed in the genome of several organisms. Dr. Kouzarides' group at Cambridge University re-analyzed a vast amount of RNA-sequencing data, and identified -600 IncRNAs that were "positionally conserved" (pcRNAs) in human and mo use genomes. Among the genes associated with these pcRNAs, a striking enrichment was obser…
Transcriptomic meta-analysis of positionally conserved long noncoding RNAs, AP.R