Search of compounds and peptides with potential antiviral activity against Arbovirus of clinical importance

• Grant number: 17/13341-1
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2018
• End date: July 31, 2020
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Carolina Colombelli Pacca
• Grantee: Carolina Colombelli Pacca
• Host Institution: Faculdade de Medicina em São José do Rio Preto (FACERES). São José do Rio Preto , SP, Brazil

Abstract

Arboviruses are diseases caused by arboviruses, which are viruses transmitted between vertebrate hosts susceptible to hematophagous arthropods. They are often associated with outbreaks in humans and represent a serious public health problem. They have a wide geographical distribution, covering all continents. By 2015, at least nine pathogenic arboviruses that cause diseases in humans have circulated in Brazil, accounting for approximately 30% of all emerging infectious diseases in the last decade, where the main representatives are the Mayaro Alphavirus (MAYV) and Chikungunya (CHIKV) , Dengue Flaviviruses (DENV), Yellow Fever (YFV), Zika (ZIKV), Saint Louis Encephalitis (SLEV) and Rocio (ROCV) and Orthobunyavirus Oropouche (OROV). Such infections generate significant costs to the Federal Government (more than 120 million reais in diagnostic tests for Zika in 2016) and do not present specific treatment for this and the development of drugs against infections by these viruses would be of great value to public health for bringing great advances in the treatment of diseases. Therefore, the objective of this study is to search for new molecules that inhibit viral replication, due to the fact that up to the present moment there are no effective molecules against the viruses MAY, ORO, SLEV and YFV. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

EBERLE, RAPHAEL J.; OLIVIER, DANILO S.; AMARAL, MARCOS S.; PACCA, CAROLINA C.; NOGUEIRA, MAURICIO L.; ARNI, RAGHUVIR K.; WILLBOLD, DIETER; CORONADO, MONIKA A.. Riboflavin, a Potent Neuroprotective Vitamin: Focus on Flavivirus and Alphavirus Proteases. MICROORGANISMS, v. 10, n. 7, p. 19-pg., 2022-07-01. (17/13341-1, 20/08615-8)

OLIVEIRA, DEBORA MORAES DE; SANTOS, IGOR DE ANDRADE; SILVA MARTINS, DANIEL OLIVEIRA; GONCALVES, YASMIM GARCIA; CARDOSO-SOUSA, LEIA; SABINO-SILVA, ROBINSON; VON POELHSITZ, GUSTAVO; FRANCA, EDUARDO DE FARIA; NICOLAU-JUNIOR, NILSON; PACCA, CAROLINA COLOMBELLI; et al. Organometallic Complex Strongly Impairs Chikungunya Virus Entry to the Host Cells. FRONTIERS IN MICROBIOLOGY, v. 11, DEC 15 2020. (17/13341-1)