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Search of compounds and peptides with potential antiviral activity against Arbovirus of clinical importance

Grant number: 17/13341-1
Support type:Regular Research Grants
Duration: May 01, 2018 - July 31, 2020
Field of knowledge:Health Sciences - Medicine
Principal researcher:Carolina Colombelli Pacca
Grantee:Carolina Colombelli Pacca
Home Institution: Faculdade Faceres. Instituto Superior de Educação Ceres (UNICERES). São José do Rio Preto , SP, Brazil

Abstract

Arboviruses are diseases caused by arboviruses, which are viruses transmitted between vertebrate hosts susceptible to hematophagous arthropods. They are often associated with outbreaks in humans and represent a serious public health problem. They have a wide geographical distribution, covering all continents. By 2015, at least nine pathogenic arboviruses that cause diseases in humans have circulated in Brazil, accounting for approximately 30% of all emerging infectious diseases in the last decade, where the main representatives are the Mayaro Alphavirus (MAYV) and Chikungunya (CHIKV) , Dengue Flaviviruses (DENV), Yellow Fever (YFV), Zika (ZIKV), Saint Louis Encephalitis (SLEV) and Rocio (ROCV) and Orthobunyavirus Oropouche (OROV). Such infections generate significant costs to the Federal Government (more than 120 million reais in diagnostic tests for Zika in 2016) and do not present specific treatment for this and the development of drugs against infections by these viruses would be of great value to public health for bringing great advances in the treatment of diseases. Therefore, the objective of this study is to search for new molecules that inhibit viral replication, due to the fact that up to the present moment there are no effective molecules against the viruses MAY, ORO, SLEV and YFV. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, DEBORA MORAES DE; SANTOS, IGOR DE ANDRADE; SILVA MARTINS, DANIEL OLIVEIRA; GONCALVES, YASMIM GARCIA; CARDOSO-SOUSA, LEIA; SABINO-SILVA, ROBINSON; VON POELHSITZ, GUSTAVO; FRANCA, EDUARDO DE FARIA; NICOLAU-JUNIOR, NILSON; PACCA, CAROLINA COLOMBELLI; MERITS, ANDRES; HARRIS, MARK; GOMES JARDIM, ANA CAROLINA. Organometallic Complex Strongly Impairs Chikungunya Virus Entry to the Host Cells. FRONTIERS IN MICROBIOLOGY, v. 11, DEC 15 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.