Investigation of natural compounds with potential antiviral activity against Mayar...
| Grant number: | 17/13341-1 |
| Support type: | Regular Research Grants |
| Duration: | May 01, 2018 - April 30, 2020 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal Investigator: | Carolina Colombelli Pacca |
| Grantee: | Carolina Colombelli Pacca |
| Home Institution: | Faculdade Faceres. Instituto Superior de Educação Ceres (UNICERES). São José do Rio Preto , SP, Brazil |
Abstract
Arboviruses are diseases caused by arboviruses, which are viruses transmitted between vertebrate hosts susceptible to hematophagous arthropods. They are often associated with outbreaks in humans and represent a serious public health problem. They have a wide geographical distribution, covering all continents. By 2015, at least nine pathogenic arboviruses that cause diseases in humans have circulated in Brazil, accounting for approximately 30% of all emerging infectious diseases in the last decade, where the main representatives are the Mayaro Alphavirus (MAYV) and Chikungunya (CHIKV) , Dengue Flaviviruses (DENV), Yellow Fever (YFV), Zika (ZIKV), Saint Louis Encephalitis (SLEV) and Rocio (ROCV) and Orthobunyavirus Oropouche (OROV). Such infections generate significant costs to the Federal Government (more than 120 million reais in diagnostic tests for Zika in 2016) and do not present specific treatment for this and the development of drugs against infections by these viruses would be of great value to public health for bringing great advances in the treatment of diseases. Therefore, the objective of this study is to search for new molecules that inhibit viral replication, due to the fact that up to the present moment there are no effective molecules against the viruses MAY, ORO, SLEV and YFV. (AU)