Prevalence and molecular epidemiology of methicillin-resistant Staphylococcus aureus in special populations

• Grant number: 17/21396-0
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2018
• End date: July 31, 2020
• Field of knowledge: Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
• Principal Investigator: Maria de Lourdes Ribeiro de Souza da Cunha
• Grantee: Maria de Lourdes Ribeiro de Souza da Cunha
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• City of the host institution: Botucatu

Abstract

Characteristics of inhabitants, living conditions, communities with agglomerations of people, underlying diseases (such as diabetes), injecting drug use, and frequency of antibiotic use contribute to the selection of resistant bacteria. We continue to fail to contain the spread of resistance genes, which already pose a threat to the health of populations. Currently, multidrug-resistant microorganisms are already responsible for infectious conditions acquired in the community. An important example is MRSA (Methicillin-resistant Staphylococcus aureus), which represents a serious public health risk worldwide due to the rapid spread and diversification of pandemic clones with increasing virulence and antimicrobial resistance. MRSA are one of the leading causes of nosocomial or health care-related infections (Healthcare-associade [HA] -MRSA), and the prevalence of this microorganism in community-associated (CA) -MRSA has increased. . However, the studies are heterogeneous in terms of objectives and methods and do not allow a complete and coherent picture of CA-MRSA epidemiology. This gap is particularly relevant in our country, where data on CA-MRSA are scarce. Therefore, this study proposes a greater investigation on the epidemiology of S. aureus and MRSA in insulin-dependent diabetic subjects and the elderly in the home care or institutionalized, to determine the nasal and oral prevalence of these microorganisms and the risk factors for colonization. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

SILVA, LUCAS PORANGABA; CASTELO BRANCO FORTALEZA, CARLOS MAGNO; TEIXEIRA, NATHALIA BIBIANA; POIANAS SILVA, LUIS THADEO; DE ANGELIS, CAROLINA DESTRO; RIBEIRO DE SOUZA DA CUNHA, MARIA DE LOURDES. Molecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilities. ANTIBIOTICS-BASEL, v. 11, n. 11, p. 16-pg., 2022-11-01. (17/21396-0)

TEIXEIRA, NATHALIA BIBIANA; CASTELO BRANCO FORTALEZA, CARLOS MAGNO; DE SOUZA, MATHEUS CRISTOVAM; MONTEIRO PEREIRA, THAIS ALINE; DE CAMARGO COLENCI, BIBIANA PRADA; RIBEIRO DE SOUZA DA CUNHA, MARIA DE LOURDES. Molecular characterization of methicillin-resistant Staphylococcus aureus among insulin-dependent diabetic individuals in Brazil. ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS, v. 20, n. 1, FEB 10 2021. (17/21396-0)

MARTINS, KATHERYNE BENINI; FERREIRA, ADRIANO MARTISON; PEREIRA, VALERIA CATANELI; PINHEIRO, LUIZA; DE OLIVEIRA, ADILSON; RIBEIRO DE SOUZA DA CUNHA, MARIA DE LOURDES. In vitro Effects of Antimicrobial Agents on Planktonic and Biofilm Forms of Staphylococcus saprophyticus Isolated From Patients With Urinary Tract Infections. FRONTIERS IN MICROBIOLOGY, v. 10, JAN 28 2019. (17/21396-0)