Genetic Diversity non-polio enterovirus detected in patients with acute flaccid paralysis in São Paulo State.

• Grant number: 17/05350-0
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2018
• End date: November 30, 2021
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Rita de Cássia Compagnoli Carmona
• Grantee: Rita de Cássia Compagnoli Carmona
• Host Institution: Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated scholarship(s): 20/10484-9 - Genetic diversity non-polio enterovirus detected in patients with acute flaccid paralysis in São Paulo State, BP.TT; 19/02006-2 - Genetic diversity non-polio enterovirus detected in patients with acute flaccid paralysis in São Paulo State, BP.TT; 18/19029-2 - Genetic diversity non-polio Enterovirus detected in patients with acute flaccid paralysis in São Paulo State, BP.TT; 18/13222-5 - Genetic Diversity non-polio enterovirus detected in patients with acute flaccid paralysis in São Paulo State., BP.TT

Abstract

Acute flaccid paralysis (AFP) is the most common clinical presentation of the infection caused by the poliovirus 1, 2 and 3 (polio), occurring in 0.1-1% of infected cases. The measures implemented throughout the national territory to strengthen the epidemiological surveillance and laboratory, and intensive vaccination campaigns, since 1989 there is no detected of polio cases in the state of São Paulo, and in Brazil since 1990. In 1994, Brazil was certified like a country wild-poliovirus-free by the Pan American Health Organization (PAHO), together with the other countries of the Americas. With the eradication of wild poliovirus in Brazil and the Americas, the non-polio enteroviruses (NPEV) are becoming increasingly relevant importance in cases of acute flaccid paralysis. The epidemiological and laboratory surveillance of PFAs in the state of São Paulo has no data on the characterization of EVNP in serotypes. The development of the project will allow the monitoring and improvement in knowledge of the diversity of the serotypes of EVNP in our country, considered as one of the main etiological agents of AFPs, and improve the existing data from other regions of Brazil. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARMONA, RITA C. C.; MACHADO, BRAULIO C.; REIS, FABRICIO C.; JORGE, ADRIANA M. V.; CILLI, AUDREY; DIAS, AMANDA M. N.; MORAIS, DANIELE R.; LEME, LUCAS; YU, ANA L. F.; SILVA, MARCELA R.; et al. Hand, foot, and mouth disease outbreak by Coxsackievirus A6 during COVID-19 pandemic in 2021, Sao Paulo, Brazil. Journal of Clinical Virology, v. 154, p. 4-pg., 2022-07-24. (17/50333-7, 17/05350-0)