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Unraveling the Ehrlichia canis life cycle in the Rhipicephalus sanguineus(tropical lineage) tick: na essential step to the controlo of canine ehrlichiosis

Grant number: 18/06651-7
Support Opportunities:Regular Research Grants
Start date: August 01, 2018
End date: July 31, 2019
Field of knowledge:Biological Sciences - Zoology - Applied Zoology
Principal Investigator:Maria Izabel Souza Camargo
Grantee:Maria Izabel Souza Camargo
Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil
Associated researchers: Ana Isabel Amaro Gonçalves Domingos ; Darci Moraes Barros-Battesti ; Gustavo Seron Sanches ; Joana Isabel Figueira Ferrolho ; Joana Manuel Gonçalves Teixeira Couto ; José de Jesús de la Fuente Garcia ; Marcos Rogério André ; Rosangela Zacarias Machado ; Sandra Isabel da Conceição Antunes
Associated scholarship(s):18/18504-9 - Unraveling the Ehrlichia canis life cycle in the Rhipicephalus sanguineus (tropical lineage) tick: an essential step to the control of canine ehrlichiosis, BP.TT

Abstract

Canine monocytic ehrlichiosis is an important multisystemic diseasethat affects canids, being considered one of the most serious infectiousdiseases of veterinary importance, with strong social and economic impact.Its etiologic agent is the obligate intracellular bacterium Ehrlichia canis,belonging to the family Anaplasmataceae, that presents tropism by monocytesand macrophages, invading them and multiplying in their interior. The tickRhipicephalus sanguineus sensu lato is the main biological vector of E. canis,however, other species may play important role in transmitting the disease indifferent parts of the world. The cycle of E. canis in the vertebrate hosts is wellknown, whereas the information about the cycle of the bacterium in its hostsvectors is still scarce and old. It is believed that the bacterium multiplies inhemocytes and salivary gland cells of ticks, providing transstadial transmission.The knowledge of the the pathogen pathway since its entrance until its arrival inthe salivary glands, as well as for how long it remains in each organ and if thereis a specific period to the transmission of this pathogen is of paramountimportance for the development of strategies and to identify and select potentialmolecules to be used as vaccine candidates. Considering that to date there isno information on this matter, the objective of this project is to study the lifecycle of E. canis in the R. sanguineus vector. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANCHES, GUSTAVO SERON; VILLAR, MARGARITA; COUTO, JOANA; FERROLHO, JOANA; FERNANDEZ DE MERA, ISABEL G.; ANDR, MARCOS ROGERIO; BARROS-BATTESTI, DARCI MORAES; MACHADO, ROSANGELA ZACARIAS; BECHARA, GERVASIO HENRIQUE; MATEOS-HERNANDEZ, LOURDES; et al. Comparative Proteomic Analysis of Rhipicephalus sanguineus sensu lato (Acari: Ixodidae) Tropical and Temperate Lineages: Uncovering Differences During Ehrlichia canis Infection. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 10, . (18/06651-7)