Objective tumoral response, safety profile and survival rates of patients with liver cirrhosis and hepatocellular carcinoma of intermediate stage submitted to Radioembolization with 131I-Lipiodol versus Transarterial Chemoembolization

• Grant number: 17/25592-9
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2018
• End date: April 30, 2022
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Fernando Gomes Romeiro
• Grantee: Fernando Gomes Romeiro
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Fábio Cardoso de Carvalho ; Felipe Aguera Oliver ; Katia Hiromoto Koga ; Marjorie do Val Ietsugu ; Matheus Alvarez ; Nelci Antunes de Moura ; Sonia Marta Moriguchi

Abstract

The incidence and prevalence of hepatocellular carcinoma (HCC) is growing worldwide, leading to high mortality rates. The disease occurs mainly in cirrhotic patients, and the cure can be reached only when it is diagnosed early or when the tumor is submitted to adjuvant therapies to reduce the tumor size, being the transarterial chemoembolization (TACE) the most used approach to achieve this aim. Among the TACE limitations, it can not be used for patients with portal vein thrombosis (PVT), which is a frequent complication in cirrhotic patients who have HCC. Furthermore, there is a big controversy on how to compare results obtained from different locoregional therapies as TACE and transarterial radioembolization (TARE), a treatment strategy that has been successfully applied for patients with HCC because it allows reducing the tumor size even in cases of PVT. The aim of this study is to compare the efficacy of TACE and TARE on the reduction of the target HCC tumor applying a software that was specifically developed by this group of researchers, allowing to measure the tumor before and after the treatment with great accuracy on computed tomography exams. Forty subjects with intermediate HCC submitted to TACE or TARE procedures will be evaluated. The study will be prospective, randomized and only patients with PVT will be direct to TARE without previous randomization. The locoregional response, the adverse events and the survival rates will be measured and compared between TARE and TACE, leading to suggestions about the individualization of these patients' treatment. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KAWANAMI, GUSTAVO HIDEKI; KATSUDA, LEOPOLDO; ROCHA, THIARA BARCELOS; DA SILVA YAMASHIRO, FABIO; PELAFSKY, LEONARDO; QI, XINGSHUN; ROMEIRO, FERNANDO GOMES. How Much Time Should Be Waited and What Are the Main Findings to Evaluate the Hepatocellular Carcinoma Response to Regorafenib? A Real-Life Experience. CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v. 2021, JAN 10 2021. (17/25592-9)

SANTOS, LIVIA A. A.; LIMA, TALLES B.; DO VAL IETSUGU, MARJORIE; DE CARVALHO NUNES, HELIO R.; QI, XINGSHUN; ROMEIRO, FERNANDO G.. Anthropometric measures associated with sarcopenia in outpatients with liver cirrhosis. NUTRITION & DIETETICS, v. 76, n. 5, p. 613-619, NOV 2019. (17/25592-9, 16/07117-9, 14/22572-9)

MARCONDES, MARIANA BARROS; SUSUKI, CINTIA MITSUE PEREIRA; HOKAMA, NEWTON KEY; HOKAMA, PAULA DE OLIVEIRA MONTANDON; OLIVER, FELIPE AGUERA; CHAIB, PAULO SERGIO; QI, XINGSHUN; ROMEIRO, FERNANDO GOMES. Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup?. BMC GASTROENTEROLOGY, v. 22, n. 1, p. 5-pg., 2022-09-04. (17/25592-9)

RIBEIRO, MICHELE COSTA DE OLIVEIRA; LEMOS, JULIANA VIANA BAIAO; MORAES, MARCELO PADOVANI DE TOLEDO; OLIVER, FELIPE AGUERA; ALVAREZ, MATHEUS; SILVA, GIOVANNI FARIA; QI, XINGSHUN; ROMEIRO, FERNANDO GOMES. Hepatic epithelioid hemangioendothelioma: how fast does it grow and which findings could have prevented diagnostic delay?-a case report. TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY, v. N/A, p. 9-pg., 2022-07-29. (17/25592-9)

PINHEIRO, RAFAEL SOARES; ANDRAUS, WELLINGTON; ROMEIRO, FERNANDO GOMES; DE MARTINO, RODRIGO BRONZE; DUCATTI, LILIANA; ARANTES, RUBENS MACEDO; PELAFSKY, LEONARDO; HASIMOTO, CLAUDIA NISHIDA; YAMASHIRO, FABIO DA SILVA; NACIF, LUCAS SOUTO; et al. Model for establishing a new liver transplantation center through mentorship from a university with transplantation expertise. PLoS One, v. 17, n. 3, p. 10-pg., 2022-01-01. (17/25592-9)

AMARAL SANTOS, LIVIA ALVES; LIMA, TALLES BAZEIA; QI, XINGSHUN; RUPP DE PAIVA, SERGIO ALBERTO; ROMEIRO, FERNANDO GOMES. Refining dual-energy x-ray absorptiometry data to predict mortality among cirrhotic outpatients: A retrospective study. NUTRITION, v. 85, MAY 2021. (17/25592-9, 14/22572-9)

SINKOS, CAMILA; GRILLO, THAIS GAGNO; BONINI, ANA CLARA MURARO; CARDOSO, LUCAS GONSALVES; WATANABE, ERIKA MAYUMI; CAVALCANTE, RICARDO DE SOUZA; SILVA, GIOVANNI FARIA; YAMASHIRO, FABIO DA SILVA; ROMEIRO, FERNANDO GOMES; LIMA, TALLES BAZEIA. Mixed and disseminated paracoccidioidomycosis after liver transplantation: Case report. MEDICAL MYCOLOGY CASE REPORTS, v. 32, p. 25-29, JUN 2021. (17/25592-9)

KAWANAMI, GUSTAVO HIDEKI; KATSUDA, LEOPOLDO; ROCHA, THIARA BARCELOS; DA SILVA YAMASHIRO, FABIO; PELAFSKY, LEONARDO; QI, XINGSHUN; ROMEIRO, FERNANDO GOMES. How Much Time Should Be Waited and What Are the Main Findings to Evaluate the Hepatocellular Carcinoma Response to Regorafenib? A Real-Life Experience. CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v. 2021, p. 5-pg., 2021-01-10. (17/25592-9)