Effects of Transcranial Direct Current Stimulation (tDCS) on Knee Osteoarthritis Pain in Elderly Subjects with Defective Endogenous Pain-Inhibitory System: Protocol for a Randomized Clinical Trial.

• Grant number: 17/09740-8
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2018
• End date: July 31, 2020
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Virginia Fernandes Moça Trevisani
• Grantee: Virginia Fernandes Moça Trevisani
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Felipe Fregni

Abstract

Introduction: Osteoarthritis (OA) is the main joint degenerative disease in the elderly and related to morbidity, especially due to functional inability and worsening in quality of life. Chronic pain is strongly related to OA and its management remains a great challenge. The transcranial Direct Current Stimulation (tDCS) emerged as a promising alternative treatment for these cases. It is an instrument capable of important impact in cerebral plasticity.Objective: Evaluate the efficacy of tDCS in softening chronic pain in elderly with knee OA.Methodology: a randomized controlled double-blinded clinical trial comparing tDCS and sham mode in a 2 months follow up. It will be included elderly of both gender attending in Geriatrics and Gerontology Service in UNIFESP-SP. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TEIXEIRA, PAULO E. P.; TAVARES, DANIELA R. B.; PACHECO-BARRIOS, KEVIN; BRANCO, LUIS CASTELO; SLAWKA, ERIC; KEYSOR, JULIE; TREVISANI, VIRGINIA F. M.; GROSS, DOUG K.; FREGNI, FELIPE. Development of a Clinical Prediction Rule for Treatment Success with Transcranial Direct Current Stimulation for Knee Osteoarthritis Pain: A Secondary Analysis of a Double-Blind Randomized Controlled Trial. BIOMEDICINES, v. 11, n. 1, p. 16-pg., 2023-01-01. (17/09740-8)

TAVARES, DANIELA REGINA BRANDA; OKAZAKI, JANE ERIKA FRAZAO; SANTANA, MARCIA VALERIA DE ANDRADE; PINTO, ANA CAROLINA PEREIRA NUNES; TUTIYA, KARINA KURAOKA; GAZONI, FERNANDA MARTINS; PINTO, CAMILA BONIN; SANTOS, FANIA CRISTINA; FREGNI, FELIPE; TREVISANI, VIRGINIA FERNANDES MOCA. Motor cortex transcranial direct current stimulation effects on knee osteoarthritis pain in elderly subjects with dysfunctional descending pain inhibitory system: A randomized controlled trial. BRAIN STIMULATION, v. 14, n. 3, p. 477-487, MAY-JUN 2021. (17/09740-8)