Obesity induced by hypercaloric diet: evaluation of the action of Citral in metabolic inflammation, systemic and healing of gastric ulcers

• Grant number: 18/09873-0
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2018
• End date: January 31, 2021
• Field of knowledge: Biological Sciences - Pharmacology - Ethnopharmacology
• Principal Investigator: Clélia Akiko Hiruma Lima
• Grantee: Clélia Akiko Hiruma Lima
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The World Health Organization has been warning us of the obesity epidemic that affects people of all age groups and socioeconomic groups in both developed and developing countries. Therefore, studies have demonstrated the higher prevalence of other diseases associated with obesity, such as increased susceptibility to infectious conditions, inflammatory processes and chronic diseases, including peptic ulcer disease. It is known that one of the causes for the occurrence of these pathological conditions is the low-grade chronic inflammatory process that affects obese individuals, which induces a change in the profile of inflammatory mediators, increasing the infiltrate of cells of the immune system in the adipose tissue and in the hypothalamic regions, consequently promoting significant metabolic alterations. Aiming to improve survival and provide drug alternatives for the treatment of inflammatory metabolic and systemic conditions in addition to the healing action of gastric ulcer, this project is based on previous studies of our group that reported the action of citral that presents a significant reduction in relevant pro inflammatory mediators and effective curative action of gastric ulcer lesions of animals with normal diet. Therefore, we intended to evaluate the response profile of citral using mice under a hyperlipidic diet, since obesity is associated with worse healing and a change in inflammatory markers including pro and anti-inflammatory cytokines (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OHARA, RIE; DARIO, FELIPE LIMA; EMILIO-SILVA, MAYCON TAVARES; ASSUNCAO, RENATA; RODRIGUES, VINICIUS PEIXOTO; BUENO, GABRIELA; RAIMUNDO, PRISCILA ROMANO; DA ROCHA, LUCIA REGINA MACHADO; HIRUMA-LIMA, CLELIA AKIKO. Citral Modulates MMP-2 and MMP-9 Activities on Healing of Gastric Ulcers Associated with High-Fat Diet-Induced Obesity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 5, p. 15-pg., 2023-03-01. (18/09873-0, 20/07384-2, 20/15225-1)

EMILIO-SILVA, MAYCON T.; RODRIGUES, VINICIUS P.; BUENO, GABRIELA; OHARA, RIE; MARTINS, MARINA G.; HORTA-JUNIOR, JOSE A. C.; BRANCO, LUIZ G. S.; ROCHA, LUCIA R. M.; HIRUMA-LIMA, CLELIA A.. Hypothermic Effect of Acute Citral Treatment during LPS-induced Systemic Inflammation in Obese Mice: Reduction of Serum TNF-alpha and Leptin Levels. BIOMOLECULES, v. 10, n. 10, OCT 2020. (18/10935-0, 18/09873-0, 16/13136-6)

PERICO, LARISSA LUCENA; EMILIO-SILVA, MAYCON TAVARES; OHARA, RIE; RODRIGUES, VINICIUS PEIXOTO; BUENO, GABRIELA; BARBOSA-FILHO, JOSE MARIA; ROCHA, LUCIA REGINA MACHADO DA; BATISTA, LEONIA MARIA; HIRUMA-LIMA, CLELIA AKIKO. Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases. BIOMOLECULES, v. 10, n. 2, FEB 2020. (18/10935-0, 18/09873-0, 15/14797-3)