Cold-Plasma: therapeutic action in experimental periodontitis

• Grant number: 17/25922-9
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2018
• End date: August 31, 2020
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Maíra Felonato Mendes
• Grantee: Maíra Felonato Mendes
• Host Institution: Pró-Reitoria de Pós-Graduação e Pesquisa. Centro Universitário Hermínio Ometto (UNIARARAS). Fundação Hermínio Ometto (FHO). Araras , SP, Brazil
• Associated researchers: Bruno Bellotti Lopes ; Camila Andréa de Oliveira ; Fernando Russo Costa do Bomfim ; Milton Santamaria Júnior ; Thiago Antônio Moretti de Andrade

Abstract

Periodontal disease is a chronic bacterial infection characterized by persistent inflammation affecting the periodontal tissues of protection and/or sustentation.. Periodontitis is characterized by an immunoinflammatory condition that involves all periodontal tissue, leading to progressive destruction of tooth supporting structures. Among others it is one of most responsible for bone resorption. The periodontal destruction is caused by bacterial virulence factors and directly damage tissues and induces inflammatory reactions. The intense inflammatory infiltrate in tooth and periodontium has relevance in periodontitis status, influencing the cytokine profile and the process of alveolar bone resorption, that characterize periodontal disease. The plasma (fourth state of matter) is composed of a highly ionized forming an ionic beam composed by isolated molecules, atoms, ions, electrons, photons and other reactive species, that have demonstrated ability to control and catalyze reactions with biochemical, therapeutic and antimicrobial effects, mainly related to the tissue repair. Accordingly it supposed being able to control the periodontal disease. In view of the above, it is relevant to study the use of a Cold Plasma Beam to treat experimental periodontitis to know the effects on the immunological processes involved in bone resorption aiming future perspectives to clinical applications in humans. (AU)