Clinical, echocardiography and immunologic evaluation of subclinical rheumatic heart disease in a low-income community of São Paulo.

• Grant number: 17/27035-0
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2019
• End date: June 30, 2021
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Roney Orismar Sampaio
• Grantee: Roney Orismar Sampaio
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: CARLOS EDUARDO DE BARROS BRANCO ; Flávio Tarasoutchi ; Karen Francine Köhler ; Luiza Guglielmi

Abstract

This project aims to promote the early detection of subclinical rheumatic carditis by echocardiography using the innovative criteria proposed by the World Heart Federation in 2012, joining echocardiographic, clinical, phonocardiography and immunological findings.The prevalence of this neglected disease will be estimated, filling a gap in our literature. This project has socioeconomic importance, since early detection can prevent the development of complications such as rheumatic valvular heart disease, the leading cause of heart failure and heart valve surgery in the youthful age, reducing the costs of the National Health System and increasing survival.Patients will be selected in the area of socioeconomic vulnerability in a community in São Paulo. 4200 patients will be evaluated by echocardiography and cardiac auscultation. After that, we will select two groups of patients (with intermediate and definitive criteria for rheumatic carditis) and a third group (normal, control) according to clinical and echocardiographic evaluation. These subgroups will be evaluated for immunogenetic profile for rheumatic disease.Therefore, this project is expected to validate the criteria of WHF in our population, to estimate the prevalence of subclinical rheumatic carditis, associating with different diagnostic methods. (AU)