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Studying the oncogenic role of RNA-binding proteins and non-coding RNAs in gliomas


Dr. Luiz O. Penalva and Dr. Pedro AF Galante have a long time of collaborations in the fields of cancer genomics, bioinformatics and RNA binding proteins (RBPs). They were funded by agencies, such as CNPq (400262/2014-2), FAPESP (2013/25483-4; 2013/07159-5) and NIH (R21CA205475-01) along the past. Over the past four years, Dr. Penalva visited Dr. Galante's laboratory (CNPq funding (400262/2014-2), terminated in 2017) twice a year. In this proposal, we are requesting funds from supporting a visit from Dr. Penalva. This visit will be important to let us continue with this fruitful collaboration. During the visit, Dr. Penalva and Dr. Galante will discuss and end-up the writing of 4 papers (scientific articles) that have been made in collaboration and are in the final steps of analyses and writing. Dr. Penalva and Dr. Galante will work to finish and submit two grant proposal to the NIH. Moreover, Dr. Penalva will give a mini-course on "The Biology of RNAs" and a talk about their current projects. All events will be at the Hospital Sírio-Libanês Hospital and will widely announce. Additionally, Dr. Penalva will also work on establishing a collaboration with another Research Group from the Hospital Sírio-Libanês (led by Dr. Raquel Martinez). Dr. Galante will also be involved in this collaboration. Finally, Dr. Penalva will participate in a thesis defense of a student funded by FAPESP (advisor Dr. Daisy Salvadori, UNESP). This student carried out a BEPE-FAPESP into Dr. Penalva's laboratory. Because of the above reasons, we believe that this support from FAPESP will be of great value and very important to us to keep this fruitful international collaboration. (AU)

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