GASTROINTESTINAL DYSFUNCTION IN INTENSIVE CARE UNIT PATIENTS: EPIDEMIOLOGY AND ROLE OF BIOMARKERS CITRULIN AND FATTY ACID BINDING INTESTINAL PROTEIN (I-FABP)

• Grant number: 17/19701-0
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2018
• End date: May 31, 2020
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Suzana Margareth Ajeje Lobo
• Grantee: Suzana Margareth Ajeje Lobo
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

Introduction: Gastrointestinal dysfunction (GID) represents an important clinical problem in patients admitted to an intensive care unit (ICU). There is strong evidence that GID is associated with longer hospital stay and probably higher mortality. Citrulline and fatty acid binding protein intestinal (I-FABP) have been postulated as possible markers of small bowel function, but their clinical applications in the diagnosis and management of GID are still uncertain.Objectives: The aim of this study are:1. To evaluate the prevalence of symptoms of gastrointestinal tube dysfunction (GID) in high-risk surgical patients admitted to Brazilian ICUs.2. Evaluate the correlation of the presence of dysfunction of GIT with other organ dysfunctions, length of hospital stay, postoperative complications and mortality.3. Evaluate the correlation of a cumulative fluid balance in the postoperative period with gastrointestinal complications.4. Evaluate the role of citrulline and I-FABP as early biomarkers of Gastrointestinal dysfuncion and unfavorable outcomes.Methodology: It is a substudy of the research project "EPIDEMIOLOGY AND CHARACTERIZATION OF PATIENTS OF HIGH RISK SURGERY OF BRAZIL - BraSiS Study", multicenter and observational study performed in 50 Brazilian ICUs that evaluated the epidemiology and postoperative complications in the period of April 1 till May 30, 2017. One thousand patients were included in the study. Eigthy patients were selected for the analysis of citrulline and I-FABP, which was the number of patients from this center who entered the main study "Brasília Study" during the 60 days of participation. (AU)