Genetic improvement of the Exserohilum rostratum fungus and study of monocerin effect on surgical wounds in murine model.

• Grant number: 17/26524-7
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2019
• End date: January 31, 2021
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Ana Olívia de Souza
• Grantee: Ana Olívia de Souza
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The secondary metabolite monocerin is produced by the fungus Exserohilum rostratum, and in this study, efforts will be applied for obtaining a mutant strain able to produce this compound with higher yield than the wild strain.Due to the therapeutic potential in wounds and injuries, the monocerin will be incorporated in a pharmaceutical formulation, such as a cream, for topical application in the treatment of surgically induced wounds in a murine model. The effect will be analyzed by microscopies, immunohistochemical and biochemistry techniques. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GOMES, TAINAH COLOMBO; CONRADO, RAFAEL; DE OLIVEIRA, RODRIGO CARDOSO; SELARI, PRISCILA JANE ROMANO GONCALVES; DE MELO, ITAMAR SOARES; ARAUJO, WELINGTON LUIZ; MARIA, DURVANEI AUGUSTO; DE SOUZA, ANA OLIVIA. Effect of Monocerin, a Fungal Secondary Metabolite, on Endothelial Cells. TOXINS, v. 15, n. 5, p. 18-pg., 2023-05-18. (14/19152-8, 17/26524-7)