Metabolic profile characterization of sarcopenic patients with colorectal cancer

• Grant number: 18/23428-0
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2019
• End date: May 31, 2022
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: José Barreto Campello Carvalheira
• Grantee: José Barreto Campello Carvalheira
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Maria Carolina Santos Mendes

Abstract

Recent studies indicate that the muscular depletion (sarcopenia) is a risk factor associated with worse prognosis in CCR patients. Insulin resistance is a common phenomenon in neoplasms and it has been implicated in the development of sarcopenia associated with aging. In spite of the advances in the knowledge about pathophysiological mechanisms of muscle wasting, the biological and molecular links between sarcopenia and insulin resistance remains largely unknown in patients with cancer. Thus, the purpose of this study is to investigate the body´s composition implications on quality of life, functional performance, metabolic profile and insulin sensitivity from CRC sarcopenic patients compared with non-sarcopenic. This is a cross-sectional study with forty adults diagnosed with CCR. The clinical variables will be evaluated, energy expenditure by indirect calorimetry, insulin sensitivity by hyperinsulinemic euglycemic clamp, biochemical exams, inflammatory markers and proteins related to the tumor. The body composition analysis will be assessed by computed tomography images. The comparisons between data will be performed using T student or Mann-Whitney test, the categorical variables by chi-square or Fisher test and the correlations rate by Spearman coefficient. Statistical significance establisehd when p<0.05. UNICAMP IRB approved this protocol (nº 2.832.568). (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PADILHA, DANIELA M. H.; MENDES, MARIA C. S.; LASCALA, FABIANA; SILVEIRA, MARINA N.; POZZUTO, LARA; SANTOS, LARISSA A. O.; GUERRA, LIVIA D.; MOREIRA, RAFAELLA C. L.; BRANBILLA, SANDRA R.; ADEMAR, D. C. JUNIOR; et al. Low skeletal muscle radiodensity and neutrophil-to-lymphocyte ratio as predictors of poor outcome in patients with COVID-19. SCIENTIFIC REPORTS, v. 12, n. 1, p. 11-pg., 2022-09-20. (18/23428-0)

DA CUNHA, JR., ADEMAR DANTAS; SILVEIRA, MARINA NOGUEIRA; TAKAHASHI, MARIA EMILIA SEREN; SOUZA, EDNA MARINA DE; MOSCI, CAMILA; RAMOS, CELSO DARIO; BRAMBILLA, SANDRA REGINA; PERICOLE, FERNANDO VIEIRA; PRADO, CARLA M.; MENDES, MARIA CAROLINA SANTOS; et al. Adipose tissue radiodensity: A new prognostic biomarker in people with multiple myeloma. NUTRITION, v. 86, JUN 2021. (18/23428-0)

DUARTE, MATEUS BRINGEL OLIVEIRA; LEAL, FREDERICO; ARGENTON, JULIANA LUZ PASSOS; CARVALHEIRA, JOSE BARRETO CAMPELLO. Impact of androgen deprivation therapy on mortality of prostate cancer patients with COVID-19: a propensity score-based analysis. INFECTIOUS AGENTS AND CANCER, v. 16, n. 1, NOV 25 2021. (18/23428-0)

OLIVEIRA DUARTE, MATEUS BRINGEL; LEAL, FREDERICO; PASSOS ARGENTON, JULIANA LUZ; CAMPELLO CARVALHEIRA, JOSE BARRETO. Outcomes of COVID-19 Patients under Cytotoxic Cancer Chemotherapy in Brazil. CANCERS, v. 12, n. 12, DEC 2020. (18/23428-0)

GABIATTI, CAMILA T. B.; MARTINS, MARIAN C. L.; MIYAZAKI, DANIELA L.; SILVA, LEANDRO P.; LASCALA, FABIANA; MACEDO, LIGIA T.; SANTOS MENDES, MARIA CAROLINA; CAMPELLO CARVALHEIRA, JOSE BARRETO. Myosteatosis in a systemic inflammation-dependent manner predicts favorable survival outcomes in locally advanced esophageal cancer. CANCER MEDICINE, v. 8, n. 16, p. 6967-6976, NOV 2019. (18/23428-0)

OIKAWA, KARINA HIROMOTO; JULIANI, FABIANA LASCALA; CARRILHO, LARISSA ARIEL OLIVEIRA; POZZUTO, LARA; PADILHA, DANIELA MORAIS DE HOLLANDA; SILVEIRA, MARINA NOGUEIRA; COSTA, FELIPE OSORIO; MACEDO, LIGIA TRALDI; DA CUNHA, ADEMAR DANTAS; MENDES, MARIA CAROLINA SANTOS; et al. Abdominal adiposity as a prognosis biomarker of clinical outcome in metastatic colorectal cancer. NUTRITION, v. 107, p. 7-pg., 2022-12-21. (18/23428-0)

SILVEIRA, MARINA NOGUEIRA; POZZUTO, LARA; SANTOS MENDES, MARIA CAROLINA; DA CUNHA, LORENA PIRES; COSTA, FELIPE OSORIO; MACEDO, LIGIA TRALDI; BRAMBILLA, SANDRA REGINA; CAMPELLO CARVALHEIRA, JOSE BARRETO. Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes. JOURNAL OF CLINICAL MEDICINE, v. 11, n. 10, p. 10-pg., 2022-05-01. (18/23428-0)

LASCALA, FABIANA; DA SILVA MORAES, BRUNA KAROLINE; SANTOS MENDES, MARIA CAROLINA; DE CARVALHO, MARILUCE BARBOSA; BRANBILLA, SANDRA REGINA; DA CUNHA JUNIOR, ADEMAR DANTAS; LOPES, LUIZ ROBERTO; ANDREOLLO, NELSON ADAMI; MACEDO, LIGIA TRALDI; PRADO, CARLA M.; et al. Prognostic value of myosteatosis and systemic inflammation in patients with resectable gastric cancer: A retrospective study. European Journal of Clinical Nutrition, v. 77, n. 1, p. 11-pg., 2022-09-08. (18/23428-0)

DUARTE, MATEUS B. O.; ARGENTON, JULIANA L. P.; CARVALHEIRA, JOSE B. C.. Impact of COVID-19 in Cervical and Breast Cancer Screening and Systemic Treatment in Sao Paulo, Brazil: An Interrupted Time Series Analysis. JCO GLOBAL ONCOLOGY, v. 8, p. 16-pg., 2022-06-01. (18/23428-0)