Indole alkaloid sub products of Maqui (Aristotelia chilensis) processing as food additives to Alzheimer's Disease treatment

• Grant number: 18/08426-0
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2018
• End date: November 30, 2022
• Field of knowledge: Biological Sciences - Biochemistry
• Agreement: Comisión Nacional de Investigación Científica y Tecnológica (CONICYT)
• Principal Investigator: Alexander Henning Ulrich
• Grantee: Alexander Henning Ulrich
• Principal researcher abroad: Cristian Fabian Paz Robles
• Institution abroad: Universidad de La Frontera (UFRO), Chile
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Maqui (Aristotelia chilensis) is a big business for the export of its fruit, of great antioxidant properties, which has conquered the agri-food industry. Maqui fruit and leaves have shown an important range of biological actions, including antioxidants, anti-inflammatory and analgesic, leading to obtain products as complementary therapeutic agents in the treatment of various chronic and degenerative disorders. The World Alzheimer Report (WAR) 2016 reviews research evidence that people living with dementia have poor access to appropriate healthcare and due to increasing life expectancy, the number of people with dementia is increasing. WAR 2016 estimates that 46.8 million people worldwide living with dementia in 2015 and this number will reach 131.5 million in 2050 (Prince et al. 2016).The Maqui plant has bioactive molecules that can give an added value. Studies by our group of researchers have isolated indole alkaloids that inhibit AChE, an enzyme associated with neurodegenerative diseases such as Alzheimer's. The indolic alkaloids have already been proposed as therapy against Alzheimer's, in this work we will extend the state of the art to new molecules extracted from Maqui, a plant endemic to Chile, as a nutritional supplement that retards and protects from the neurodegenerative effects of Alzheimer's disease. Dr. Paz and coworkers published in 2017 the first report of cholinesterases (AChE) inhibitors indole alkaloids from A. chilensis. This publication is considered as the starting point of this project in order to evaluate the role of this indole alkaloids in vivo, and propose it for use as functional food or nutraceuticals for aging people. (AU)

Scientific publications

(15)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANDREJEW, ROBERTA; GLASER, TALITA; OLIVEIRA-GIACOMELLI, AGATHA; RIBEIRO, DEIDIANE; GODOY, MARIANA; GRANATO, ALESSANDRO; ULRICH, HENNING; RATAJCZAK, MZ. Targeting Purinergic Signaling and Cell Therapy in Cardiovascular and Neurodegenerative Diseases. STEM CELLS: THERAPEUTIC APPLICATIONS, v. 1201, p. 79-pg., 2019-01-01. (18/08426-0, 19/05384-8, 15/13345-1, 12/50880-4)

MARQUES, BRUNO LEMES; OLIVEIRA-LIMA, ONESIA CRISTINA; CARVALHO, GUSTAVO ALMEIDA; CHIARELLI, RAPHAELA DE ALMEIDA; RIBEIRO, RAUL IZIDORO; PARREIRA, RICARDO CAMBRAIA; DA MADEIRA FREITAS, ELIS MARRA; RESENDE, RODRIGO RIBEIRO; KLEMPIN, FRIEDERIKE; ULRICH, HENNING; et al. Neurobiology of glycine transporters: From molecules to behavior. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 118, p. 97-110, NOV 2020. (18/08426-0)

OLIVEIRA-GIACOMELLI, AGATHA; PETIZ, LYVIA LINTZMAIER; ANDREJEW, ROBERTA; TURRINI, NATALIA; SILVA, JEAN BEZERRA; SACK, ULRICH; ULRICH, HENNING. Role of P2X7 Receptors in Immune Responses During Neurodegeneration. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 15, MAY 26 2021. (18/08426-0, 19/24553-5, 18/07366-4, 19/26852-0, 20/10725-6)

ULRICH, HENNING; PILLAT, MICHELI M.; TARNOK, ATTILA. Dengue Fever, COVID-19 (SARS-CoV-2), and Antibody-Dependent Enhancement (ADE): A Perspective. Cytometry Part A, v. 97, n. 7, p. 6-pg., 2020-06-07. (18/08426-0)

PILLAT, MICHELI MAINARDI; AYUPE, ANA CAROLINA; JUVENAL, GUILHERME; MEINERZ, CARINE; GLASER, TALITA; DA SILVA PELLEGRINA, DIOGO VIEIRA; PAIVA, DAISYLEA SOUZA; MELLO, CARLOS FERNANDO; LONGO, BEATRIZ MONTEIRO; REIS, EDUARDO MORAES; et al. Differentiated Embryonic Neurospheres from Familial Alzheimer's Disease Model Show Innate Immune and Glial Cell Responses. STEM CELL REVIEWS AND REPORTS, v. 19, n. 6, p. 12-pg., 2023-05-02. (18/07366-4, 18/08426-0)

GLASER, TALITA; OLIVEIRA-GIACOMELLI, AGATHA; PETIZ, LYVIA LINTZMAIER; RIBEIRO, DEIDIANE ELISA; ANDREJEW, ROBERTA; ULRICH, HENNING. Antagonistic Roles of P2X7 and P2Y2 Receptors in Neurodegenerative Diseases. FRONTIERS IN PHARMACOLOGY, v. 12, p. 7-pg., 2021-04-12. (18/08426-0, 18/17504-5, 19/24553-5, 19/26852-0, 15/13345-1, 18/07366-4)

ULRICH, HENNING; PILLAT, MICHELI M.. CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement. STEM CELL REVIEWS AND REPORTS, v. 16, n. 3, p. 7-pg., 2020-04-20. (18/08426-0)

ULRICH, HENNING; PILLAT, MICHELI M.; TARNOK, ATTILA. Dengue Fever, COVID-19 (SARS-CoV-2), and Antibody-Dependent Enhancement (ADE): A Perspective. Cytometry Part A, v. 97, n. 7, SI, JUN 2020. (18/08426-0)

ULRICH, HENNING; PILLAT, MICHELI M.. CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement. STEM CELL REVIEWS AND REPORTS, v. 16, n. 3, APR 2020. (18/08426-0)

RIBEIRO, DEIDIANE ELISA; RONCALHO, ALINE LULHO; GLASER, TALITA; ULRICH, HENNING; WEGENER, GREGERS; JOCA, SAMIA. P2X7 Receptor Signaling in Stress and Depression. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 11, JUN 1 2019. (15/13345-1, 12/50880-4, 18/08426-0)

RODRIGUEZ-MASSO, SERGIO R.; ERICKSON, MICHELLE A.; BANKS, WILLIAM A.; ULRICH, HENNING; MARTINS, ANTONIO HENRIQUE. The Bradykinin B2 Receptor Agonist (NG291) Causes Rapid Onset of Transient Blood-Brain Barrier Disruption Without Evidence of Early Brain Injury. FRONTIERS IN NEUROSCIENCE, v. 15, DEC 15 2021. (18/08426-0)

DUARTE-SILVA, EDUARDO; ULRICH, HENNING; OLIVEIRA-GIACOMELLI, AGATHA; HARTUNG, HANS-PETER; MEUTH, SVEN G.; PEIXOTO, CHRISTINA ALVES. The adenosinergic signaling in the pathogenesis and treatment of multiple sclerosis. FRONTIERS IN IMMUNOLOGY, v. 13, p. 10-pg., 2022-07-28. (18/07366-4, 18/08426-0, 19/26852-0)

RIBEIRO, DEIDIANE ELISA; PETIZ, LYVIA LINTZMAIER; GLASER, TALITA; OLIVEIRA-GIACOMELLI, AGATHA; ANDREJEW, ROBERTA; SAAB, FERNANDO DE AZEVEDO RIBEIRO; MILANIS, MILENA DA SILVA; CAMPOS, HENRIQUE CORREIA; SAMPAIO, VANESSA FERNANDES ARNAUD; LA BANCA, SOPHIA; et al. Purinergic signaling in cognitive impairment and neuropsychiatric symptoms of Alzheimer's disease. Neuropharmacology, v. 226, p. 16-pg., 2023-01-12. (18/07366-4, 18/08426-0, 18/17504-5, 15/19128-2)

RIBEIRO, DEIDIANE ELISA; RONCALHO, ALINE LULHO; GLASER, TALITA; ULRICH, HENNING; WEGENER, GREGERS; JOCA, SAMIA. P2X7 Receptor Signaling in Stress and Depression. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 11, p. 26-pg., 2019-06-01. (18/08426-0, 15/13345-1, 12/50880-4)

VILLEGAS, CECILIA; PEREZ, REBECA; PETIZ, LYVIA LINTZMAIER; GLASER, TALITA; ULRICH, HENNING; PAZ, CRISTIAN. Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease. IUBMB Life, v. 74, n. 8, p. 17-pg., 2022-04-05. (18/08426-0, 18/07366-4, 21/00060-0)