Effects of aging and sexual dimorphism in hydromineral balance: analysis of hypothalamic transcriptome and intracellular signaling pathways

• Grant number: 19/02465-7
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2019
• End date: May 31, 2021
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: José Antunes Rodrigues
• Grantee: José Antunes Rodrigues
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Aging has systemic consequences that can be classified into four processes: body composition, balance between availability and energy demand, network of signs that control homeostasis and neurodegeneration. The characteristic of the normal aging process is a decline in the physiological reserve in many regulatory systems of the body, including those involved in the maintenance of fluid balance. In adult women, estrogens and progestogens can influence the hormonal and neural system that control thirst, fluid intake, sodium appetite, and renal sodium excretion. However, in menopausal women, the plasma concentration of these hormones decreases and therefore may modify the hydromineral balance. It has also been described that, in mice, estradiol (E2) modulates the arcuate nucleus (ARQ), influencing energy homeostasis. Based on the above, the objective of this study is to analyze the effect of sex, age, treatment with 17²-estradiol and dehydration on the hypothalamic transcriptome and interaction of estradiol intracellular signaling pathways with angiotensin II responses. (AU)