Synthesis and physical-chemical characterization of a cotton-wool-like nanofibers biopolymer of graphene oxide

• Grant number: 19/06045-2
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2019
• End date: October 31, 2021
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Principal Investigator: Rafael Francisco Lia Mondelli
• Grantee: Rafael Francisco Lia Mondelli
• Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil

Abstract

The high incidence of resin composite restorations replacements' highlights the requirement of new restorative materials development. The last decades have shown a rapid and growing advance in nanomaterials. The discovery of graphene is considered to be one of the major forces that boosted nanotechnology thus generating great interest from scientists around the world. In the field of tissue engineering, new hybrid biomaterials composed of organic and inorganic phases have been researched as a grouping of reinforced physical-chemical properties. The doping process of bioactive hybrids in the configuration of nanofibers (cotton wool-like) with graphene oxide represents an innovative feature of this research project, since it presents similar color to dental structures and can be used in restorative materials with potential for increase the longevity of resin composite restorations with satisfactory optical properties. A resin matrix will be prepared (49.5% BisGMA, 49.5% TEGDMA, 2- dimethacrylate 0.8% and camphorquinone 0.2%) and hybrid nanofibers (200 nm) of Poly (lactide acid) + Silica (1%, 2%, 4%, 8% and 12%) doped with functionalized graphene oxide (1%, 2% and 5%) will be incorporated. The nanofibers will be characterized regarding their physical-chemical properties, which involves morphology aspects, degree of thermic degradability and composition. Afterward, the developed biopolymer will be analyzed by FTIR (n=3), 3-point flexural strength (n=10), modulus of elasticity (n=10), SEM images (n=3) and Knoop hardness (n=5). Lastly, in order to approach this study of that found on in vivo conditions, an in vitro Simulated Body Fluid test will be performed in order to determine the apatite formation of the specimens, after immersion in the saturated solution at 37°C in an incubator and evaluated by FTIR and X-ray diffraction after (1,12,24,72,168 and 336 hs) of immersion. The quantitative data will be submitted to two-way ANOVA and Tukeys' test (p<0.05). (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VELO, MARILIA M. A. C.; NASCIMENTO, TATIANA R. L.; SCOTTI, CASSIANA K.; BOMBONATTI, JULIANA F. S.; FURUSE, ADILSON Y.; SILVA, VINICIUS D.; SIMOES, THIAGO A.; MEDEIROS, ELITON S.; BLAKER, JONNY J.; SILIKAS, NIKOLAOS; et al. Improved mechanical performance of self-adhesive resin cement filled with hybrid nanofibers-embedded with niobium pentoxide. Dental Materials, v. 35, n. 11, p. E272-E285, NOV 2019. (19/06045-2)

MARILIA MATTAR DE AMOÊDO CAMPOS VELO; TATIANA RITA DE LIMA NASCIMENTO; ALYSSA TEIXEIRA OBEID; NAIR CRISTINA MARGARIDO BRONDINO; RAFAEL FRANCISCO LIA MONDELLI. Evaluation of contact angle and mechanical properties of resin monomers filled with graphene oxide nanofibers. Brazilian Dental Journal, v. 34, n. 4, p. 127-134, 2023-10-27. (19/06045-2)

DE LIMA NASCIMENTO, TATIANA RITA; DE AMOEDO CAMPOS VELO, MARILIA MATTAR; SILVA, CAMILA FELIX; SILVA COSTA CRUZ, SARA BRITO; CAVALCANTI GONDIM, BRENNA LOUISE; LIA MONDELLI, RAFAEL FRANCISCO; CANCADO CASTELLANO, LUCIO ROBERTO. Current Applications of Biopolymer-based Scaffolds and Nanofibers as Drug Delivery Systems. CURRENT PHARMACEUTICAL DESIGN, v. 25, n. 37, p. 3997-4012, 2019. (19/06045-2)

OBEID, ALYSSA TEIXEIRA; ANTUNES GARCIA, LUISA HELENA; DE LIMA NASCIMENTO, TATIANA RITA; CANCADO CASTELLANO, LUCIO ROBERTO; SOARES BOMBONATTI, JULIANA FRAGA; HONORIO, HEITOR MARQUES; LIA MONDELLI, RAFAEL FRANCISCO; SAURO, SALVATORE; DE AMOEDO CAMPOS VELO, MARILIA MATTAR. Effects of hybrid inorganic-organic nanofibers on the properties of enamel resin infiltrants - An in vitro study. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 126, p. 10-pg., 2022-02-01. (19/06045-2, 19/10840-2)

ALYSSA TEIXEIRA OBEID; TATIANA RITA DE LIMA NASCIMENTO; ANA CAROLINA AGASSI; ANA ZÉLIA FALCÃO ALMEIDA; ANA PAULA DE MELO ALVES GUEDES; JOÃO MARCO ALVES; JULIANA FRAGA SOARES BOMBONATTI; MARILIA MATTAR DE AMOÊDO CAMPOS VELO. Niobium oxyhydroxide as a bioactive agent and reinforcement to a high-viscosity bulk-fill resin composite. Journal of Applied Oral Science, v. 32, 2024-03-22. (19/06045-2)