Structural dissection of nanoparticle-assisted drug delivery in human infectious diseases

• Grant number: 19/00899-0
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2019
• End date: August 31, 2020
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Agreement: Universität Hamburg (UHH)
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Carsten Wrenger
• Grantee: Carsten Wrenger
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 15/26722-8 - Drug discovery against human infectious diseases, AP.TEM

Abstract

In terms of the proposed collaborative research and educational activities the applicants plan to initiate a long term collaboration, particular involving young scientists and PhD students, in distinct research topics covering drug discovery, drug design and drug delivery. The complementary expertise of the applicants and Institutions involved will be first focused and merged to identify and optimize drug compounds, including drug delivery methods to target selected infectious diseases which are already investigated within local research activities at UHH and USP. The research initiative will utilize latest biophysical and bioanalytical methods and technologies established at UHH and USP and at the research Campus DESY, Hamburg, allowing them to obtain unique data and results in the field of drug discovery. The pilot investigations will focus on the vitamin B6 metabolism of parasites and bacteria, an innovative drug target system. The research collaboration will publish results in time, allowing to set up and to prepare an extended research proposal, including more faculties and departments at UHH and USP, as bioinformatics, chemistry, biology and medicine, to be submitted to appropriate funding agencies, to obtain support for a medium to long term collaboration. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

WUNDERLICH, GERHARD; BETZEL, CHRISTIAN; WRENGER, CARSTEN. Editorial: From Apicomplexan Genes to Drug Discovery. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, p. 2-pg., 2021-11-10. (15/26722-8, 19/00899-0, 17/24267-7)

SRINIVASAN, VASUNDARA; BROGNARO, HEVILA; PRABHU, PRINCE R.; DE SOUZA, EDMARCIA ELISA; GUENTHER, SEBASTIAN; REINKE, PATRICK Y. A.; LANE, THOMAS J.; GINN, HELEN; HAN, HUIJONG; EWERT, WIEBKE; et al. Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease. COMMUNICATIONS BIOLOGY, v. 5, n. 1, p. 12-pg., 2022-08-11. (15/26722-8, 19/00899-0, 20/12277-0)