Interaction of diesel particulate material (DEP) and sexual hormones (estrogen, progesterone and testosterone) in endocrine metabolism and xenobiotics in BEAS-2B (human bronchic epitelic cells)

• Grant number: 19/00183-4
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2019
• End date: March 31, 2023
• Field of knowledge: Biological Sciences - Pharmacology - Toxicology
• Principal Investigator: Mariangela Macchione
• Grantee: Mariangela Macchione
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Bryan Eric Strauss ; Daniela Perroni Frias ; Kelly Yoshizaki ; Thais Mauad

Abstract

Air pollution today is the subject of much research directly related to human health. There is much data suggesting that air pollution causes many cardiorespiratory diseases among other factors and that it can affect women much more than men. Among the main pollutants studied, diesel exhaust particles (DEP) have a great ability to mimic estrogen hormones, and can act in the metabolic pathways of the same. Or another suggestion, it would be estrogen itself acting in the xenobiotic metabolism pathway (aryl hydrocarbon pathway), increasing this female predisposition to chronic respiratory diseases. Thus, this study seeks to identify alterations in the endocrine and xenobiotic metabolic pathways; and cell viability of human bronchial epithelial cells (BEAS-2B), associated with high concentrations of sex hormones such as estrogen, progesterone and testosterone when exposed to this diesel particulate matter. (AU)