RFID biosensors for in-hospital detection of infectious bacteria and fungi

• Grant number: 19/07589-6
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: February 01, 2020
• End date: January 31, 2022
• Field of knowledge: Interdisciplinary Subjects
• Agreement: FINEP - PIPE/PAPPE Grant
• Principal Investigator: Gabriela Byzynski Soares
• Grantee: Gabriela Byzynski Soares
• Company: Nanochemtech Pesquisa e Desenvolvimento em Biomateriais Ltda
• CNAE: Pesquisa e desenvolvimento experimental em ciências físicas e naturais ; Atividades de serviços de complementação diagnóstica e terapêutica ; Atividades de apoio à gestão de saúde
• Associated researchers: Cauê Ribeiro de Oliveira ; Filippo Ghiglieno
• Associated research grant: 17/22645-4 - RFID biosensors for detecting bacteria and fungi causing hospital infections, AP.PIPE
• Associated scholarship(s): 21/13150-7 - RFID biosensor for hospital environment bacteria and fungi detection responsible for hospital infection, BP.TT; 21/04823-8 - RFID biosensors for environmental hospitalar detection of infection bacteria and fungi, BP.TT; 21/04552-4 - RFID biosensor for hospital environment bacteria and fungi detection responsible for hospital infection, BP.TT; + associated scholarships 20/02748-6 - RFID biosensors for in-hospital detection of infectious bacteria and fungi, BP.TT; 20/04714-1 - RFID biosensors for in-hospital detection of infectious bacteria and fungi, BP.TT; 20/01827-0 - RFID biosensors for in-hospital detection of infectious bacteria and fungi, BP.PIPE - associated scholarships

Abstract

A major national problem for collective health is hospital infections, which result in an increase in the patient's hospitalization time and also in the mortality rate. The monitoring of the hospital environment and medical clinics is one of the decisive factors for the reduction of hospital infection rates. Thus, the PIPE project aims to obtain a commercial prototype of a Radio Frequency Identification (RFID) biosensor deposited in plastic support, with the objective of rapid and cheap detection of the main infectious agents in the hospital environment, capable of generating frames contamination. The deposition of specific organic material, described in more detail throughout the project, aims to obtain a more biocompatible device on the RFID tag and to aid in the binding and stability of the biosensor, as well as improvements in the electrical signal of the biosensor. Specific and selective bio-receptor molecules for specific microorganisms (described in more detail throughout the project), allows the use of the biosensor in diversified environmental conditions, such as temperature and humidity changes. In addition, the biosensor will be selective for each pathogen. Remote reading facilitates the identification of possible contamination, giving prompt information to medical teams for preventive actions and hygiene protocols. It is intended to use this biosensor in forms of disposable reagent strips and therefore, it will be supported under thick plastic commercial substrates. Thus, the biosensor can aid in the prior detection of pathogenic microorganisms causing infections in the hospital environment, resulting in adjustable, quicker and better conditions of monitoring the environment and consequently reducing costs to hospital institutions (AU)

Filed patent(s) as a result of this research project