Comparative study between photodynamic therapy with urucum and LED and probiotics in halitosis reduction: controlled clinical trial

• Grant number: 19/14229-6
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2020
• End date: July 31, 2022
• Field of knowledge: Health Sciences - Dentistry - Dental Clinics
• Principal Investigator: Sandra Kalil Bussadori
• Grantee: Sandra Kalil Bussadori
• Host Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
• Associated researchers: David José Casimiro de Andrade

Abstract

Halitosis is a term that defines any odor or bad smell from the oral cavity, which may have local or systemic origin. This project aims to verify whether the treatment with antimicrobial photodynamic therapy (aPDT) and the treatment with probiotics are effective against it. Fifty-two students or UNINOVE employees, 18 to 25 years old, with a diagnosis of halitosis, will be selected, with sulphide (SH2) e 112 ppb in gas chromatography. Participants will be divided randomly into 4 groups of 13, who will receive different treatments: Group 1: treatment with brushing, dental floss and tongue scraper; Group 2: brushing, dental floss and aPTT applied to the back and middle third of the tongue; Group 3: brushing, dental floss and probiotics; Group 4: Brushing, flossing, aPDT and probiotics. The results of halimetry will be compared before, immediately after treatment, seven days after and thirty days after treatment. Microbiological analysis of the lingual flap will be performed at these same times. Quantitative analysis will be performed using real-time PCR. The normality of the data will be measured using the Shapiro-Wilk test, and in the case of normality the Variance Analysis (ANOVA) test will be applied, and in the case of non-parametric data, the Kruskal-Wallis test will be used. To analyze the results of each treatment in both periods of the study, the Wilcoxon test will be used. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAROLINA CARDOSO GUEDES; SANDRA KALIL BUSSADORI; ANA CAROLINA MOTA GARCIA; LARA JANSISKI MOTTA; ANDRÉA OLIVER GOMES; RAIMAR WEBER; OLGA MARIA SILVERIO AMANCIO. Accuracy of a portable breath meter test for the detection of halitosis in children and adolescents. Clinics, v. 75, 2020-09-11. (19/14229-6)

MORIYAMA, CAROLINE MORAES; SANTOS, ELAINE MARCILIO; GONCALVES, MARCELA LETICIA LEAL; TUBEL, CARLOS ALBERTO; DA SILVA, MATHEUS PEREIRA; NASCIMENTO, VICTOR AUGUSTO WHATELY; TEIXEIRA, VICTOR PEREZ; SOBRAL, ANA PAULA TABOADA; HORLIANA, ANNA CAROLINA RATTO TEMPESTINI; MOTTA, LARA JANSISKI; et al. Evaluation of the efficacy of a commercially available regimen vs brushing alone on established plaque and gingivitis on adolescents Study protocol for a randomized, controlled, blind clinical trial. MEDICINE, v. 99, n. 45, NOV 6 2020. (19/14229-6)

COSTA DA MOTA, ANA CAROLINA. Antimicrobial photodynamic therapy with Bixa orellana extract and blue LED in the reduction of halitosis-A randomized, controlled clinical trial. Photodiagnosis and Photodynamic Therapy, v. 30, JUN 2020. (19/14229-6)

MOTTA, PAMELLA DE BARROS; MOTTA, LARA JANSISKI; COSTA DA MOTA, ANA CAROLINA; LEAL GONCALVES, MARCELA LETICIA; SILVA, TAMIRIS; MOMOLLI, MARCOS; DE ANDRADE, DAVID CASIMIRO; SANTOS FERNANDES, KRISTIANNE PORTA; MESQUITA-FERRARI, RAQUEL AGNELLI; DEANA, ALESSANDRO MELO; et al. Comparative study between photodynamic therapy with urucum plus Led and probiotics in halitosis reduction-protocol for a controlled clinical trial. PLoS One, v. 16, n. 5, MAY 14 2021. (19/14229-6)

MOTTA, PAMELLA DE BARROS; GONCALVES, MARCELA LETICIA LEAL; GALLO, JULIANA MARIA ALTAVISTA SAGRETTI; SOBRAL, ANA PAULA TABOADA; MOTTA, LARA JANSISKI; MAYER, MARCIA PINTO ALVES; KAWAMOTO, DIONE; DE ANDRADE, DAVID CASIMIRO; SANTOS, ELAINE MARCILIO; FERNANDES, KRISTIANNE PORTA SANTOS; et al. Short term effect of antimicrobial photodynamic therapy and probiotic L. salivarius WB21 on halitosis: A controlled and randomized clinical trial. PLoS One, v. 19, n. 7, p. 16-pg., 2024-07-02. (19/14229-6, 22/16828-7)

BRUNO, LAURA HERMIDA; MANDETTA, AMANDA RAFAELLY HONORIO; SOBRAL, ANA PAULA TABOADA; GONCALVES, MARCELA LETICIA LEAL; SANTOS, ELAINE MARCILIO; FOSSATI, ANA LAURA; GALLO, JULIANA MARIA ALTAVISTA SAGRETTI; MOTTA, PAMELLA DE BARROS; DEANA, ALESSANDRO MELO; HORLIANA, ANNA CAROLINA RATTO TEMPESTINI; et al. Assessment of photodynamic therapy with annatto and led for the treatment of halitosis in mouth-breathing children: Randomized controlled clinical trial. PLoS One, v. 19, n. 9, p. 14-pg., 2024-09-03. (19/14229-6, 22/16828-7)