Comparative study between photodynamic therapy with urucum and LED and probiotics in halitosis reduction: controlled clinical trial

• Grant number: 19/14229-6
• Support type: Regular Research Grants
• Duration: February 01, 2020 - July 31, 2022
• Field of knowledge: Health Sciences - Dentistry - Dental Clinics
• Principal researcher: Sandra Kalil Bussadori
• Grantee: Sandra Kalil Bussadori
• Home Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
• Assoc. researchers: David José Casimiro de Andrade

Abstract

Halitosis is a term that defines any odor or bad smell from the oral cavity, which may have local or systemic origin. This project aims to verify whether the treatment with antimicrobial photodynamic therapy (aPDT) and the treatment with probiotics are effective against it. Fifty-two students or UNINOVE employees, 18 to 25 years old, with a diagnosis of halitosis, will be selected, with sulphide (SH2) e 112 ppb in gas chromatography. Participants will be divided randomly into 4 groups of 13, who will receive different treatments: Group 1: treatment with brushing, dental floss and tongue scraper; Group 2: brushing, dental floss and aPTT applied to the back and middle third of the tongue; Group 3: brushing, dental floss and probiotics; Group 4: Brushing, flossing, aPDT and probiotics. The results of halimetry will be compared before, immediately after treatment, seven days after and thirty days after treatment. Microbiological analysis of the lingual flap will be performed at these same times. Quantitative analysis will be performed using real-time PCR. The normality of the data will be measured using the Shapiro-Wilk test, and in the case of normality the Variance Analysis (ANOVA) test will be applied, and in the case of non-parametric data, the Kruskal-Wallis test will be used. To analyze the results of each treatment in both periods of the study, the Wilcoxon test will be used. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MORIYAMA, CAROLINE MORAES; SANTOS, ELAINE MARCILIO; GONCALVES, MARCELA LETICIA LEAL; TUBEL, CARLOS ALBERTO; DA SILVA, MATHEUS PEREIRA; NASCIMENTO, VICTOR AUGUSTO WHATELY; TEIXEIRA, VICTOR PEREZ; SOBRAL, ANA PAULA TABOADA; HORLIANA, ANNA CAROLINA RATTO TEMPESTINI; MOTTA, LARA JANSISKI; DE PAULA, ELOISA ANDRADE; MAGALHAES, GABRIELA TRALDI ZAFFALON DE ALMEIDA; MAGALHAES, JOSE CASSIO DE ALMEIDA; DEANA, ALESSANDRO MELO; SAKIYAMA, KYLZE IKEGAMI; BUSSADORI, SANDRA KALIL. Evaluation of the efficacy of a commercially available regimen vs brushing alone on established plaque and gingivitis on adolescents Study protocol for a randomized, controlled, blind clinical trial. MEDICINE, v. 99, n. 45 NOV 6 2020. Web of Science Citations: 0.

COSTA DA MOTA, ANA CAROLINA. Antimicrobial photodynamic therapy with Bixa orellana extract and blue LED in the reduction of halitosis-A randomized, controlled clinical trial. Photodiagnosis and Photodynamic Therapy, v. 30, JUN 2020. Web of Science Citations: 0.

CAROLINA CARDOSO GUEDES; SANDRA KALIL BUSSADORI; ANA CAROLINA MOTA GARCIA; LARA JANSISKI MOTTA; ANDRÉA OLIVER GOMES; RAIMAR WEBER; OLGA MARIA SILVERIO AMANCIO. Accuracy of a portable breath meter test for the detection of halitosis in children and adolescents. Clinics, v. 75, p. -, 2020.