Interaction between the presence of APO-E4, plasma biomarkers and the practice of physical activity on cognitive function in older population from Baixada Santista

• Grant number: 19/13343-0
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2020
• End date: April 30, 2023
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Angelina Zanesco
• Grantee: Angelina Zanesco
• Host Institution: Faculdade de Medicina. Universidade Metropolitana de Santos (UNIMES). Santos , SP, Brazil
• Associated researchers: MILENY ESBRAVATTI STEPHANO COLOVATI ; Mirlene Cecilia Soares Pinho Cernach
• Associated research grant(s): 24/09755-9 - 10th International Society for Physical Activity and Health, AR.EXT
• Associated scholarship(s): 21/13008-6 - Interaction between the allele of APOE4, cardiometabolic biomarkers and the practice of physical exercise on cognitive function and the sex differences in elderly of Baixada Santista, BP.TT; 20/09301-7 - Interaction between the allele of APOE4, cardiometabolic biomarkers and the practice of physical exercise on cognitive function and the sex differences in elderly of Baixada Santista, BP.TT

Abstract

The present study will deal with at least three questions: 1. Is there an interaction between the presence of APO- E4, plasma biomarkers and the practice of physical activity, at least for 1 year (regular swimmer or detected by IPAQ short version) and cognitive function (MEEM associated with clinical dementia rating -CDR) in older people (e 65 years) from Baixada Santista?; 2. Is there a sex difference in all parameters examined in question 1? 3. How feasible is the associate signaling pathway stimulated by physical exercise on a new strategy of therapy for preventing Alzheimer's disease or to attenuate its progression? To examine that, the present research proposal will verify the prevalence of Alzheimer's disease in Baixada Santista, approximately 734 older people will be evaluated by the MEEM. After that, the individuals will be divided into three groups: 1) physically active (detected by IPAQ short version); 2) regular swimmer 2x/week in the gym of the Faculdade de Educação Física (FEFIS) of UNIMES, and 3) physically inactive. Blood samples will be collected for biochemical and genetic analyses. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

A.P. JARRETE; L.T. GIOLLO-JUNIOR; J.F. VILELA-MARTIN; I.P. NOVAIS; M.A. DELBIN; A. ZANESCO. Alterations in pro- and anti-inflammatory mediators are involved in microvascular dysfunction in postmenopausal women with type 2 diabetes mellitus. Brazilian Journal of Medical and Biological Research, v. 55, 2022-02-28. (19/13343-0, 16/16351-5)

M.E.S. COLOVATI; I.P. NOVAIS; M. ZAMPOL; G.D. MENDES; M.C.S. CERNACH; A. ZANESCO. Interaction between physical exercise and APOE gene polymorphism on cognitive function in older people. Brazilian Journal of Medical and Biological Research, v. 54, n. 2, 2020-12-09. (19/13343-0)

JARRETE, A. P.; GIOLLO-JUNIOR, L. T.; VILELA-MARTIN, J. F.; NOVAIS, I. P.; DELBIN, M. A.; ZANESCO, A.. Alterations in pro- and anti-inflammatory mediators are involved in microvascular dysfunction in postmenopausal women with type 2 diabetes mellitus. Brazilian Journal of Medical and Biological Research, v. 55, n. 1, p. 8-pg., 2022-01-01. (19/13343-0, 16/16351-5)

PATRICIA DE OLIVEIRA LOPES; SIMONE REZENDE DA SILVA; TATHIANNI CRISTINI DA SILVA; YARA DADALTI FRAGOSO; ANGELINA ZANESCO. Cidade amiga do idoso: perspectivas futuras para as cidades brasileiras. Dement. Neuropsychol., v. 15, n. 3, p. 295-298, 2021-09-20. (19/13343-0)

SOUZA, MELYSSA ALVES; PERES BOMFIM, LARISSA GOMES; DE BARROS, VINICIUS LUCIO; MEDEIROS, REINALDO COELHO, JR.; GINSICKE, DANIELLE CRISTINE; STEPHANO COLOVATI, MILENY ESBRAVATTI; DALY, TIMOTHY; ZANESCO, ANGELINA. The Differential Effect of Schooling and Physical Activity on Dementia in Older Women and Men from Brazil: Implications for Policymaking. JOURNAL OF ALZHEIMER'S DISEASE, v. 90, n. 2, p. 9-pg., 2022-01-01. (19/13343-0)