Supramolecular assemblies with immunoadjuvant or antimicrobial activity

• Grant number: 19/17685-2
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2020
• End date: April 30, 2023
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Ana Maria Carmona-Ribeiro
• Grantee: Ana Maria Carmona-Ribeiro
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Eliana Faquim de Lima Mauro
• Associated scholarship(s): 21/01245-3 - Preparation, characterization and antimicrobial activity of nanoparticles and silica films covered by a cationic lipid bilayer incorporating gramicidin and its respective films obtained by deposition, BP.TT; 20/08078-2 - Preparation, characterization and antimicrobial activity of nanoparticles and silica films covered by a cationic lipid bilayer incorporating gramicidin and its respective films obtained by deposition, BP.TT

Abstract

Our laboratory is dedicated to the development of novel supramolecular assemblies for presenting antigens or for improving the antimicrobial action against resistant microbes. The constructions will rely on intermolecular interactions between polymers, lipids, biomolecules, surfactants, antigens and other significant molecules to build effective immunoadjuvants or microbicides.Preparation, characterization and bioactivity will be determined by classical but sometimes sophisticated techniques like dynamic light-scattering, morphology of nanoparticles, films and cells from scanning electron microscopy, determination of cells viability for microrganisms and model mammalian cells like cultured fibroblasts. Not only the effectiveness of the assemblies will be evaluated but also their toxicity. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARMONA-RIBEIRO, ANA MARIA. Supramolecular Nanostructures for Vaccines. BIOMIMETICS, v. 7, n. 1, p. 21-pg., 2022-03-01. (19/17685-2)

CARMONA-RIBEIRO, ANA MARIA; ARAUJO, PERICLES MARQUES. Antimicrobial Polymer-Based Assemblies: A Review. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 11, JUN 2021. (19/17685-2)

PEREZ-BETANCOURT, YUNYS; TAVORA, BIANCA DE CARVALHO LINS FERNANDES; FAQUIM-MAURO, ELIANA L.; CARMONA-RIBEIRO, ANA MARIA. Biocompatible Lipid Polymer Cationic Nanoparticles for Antigen Presentation. POLYMERS, v. 13, n. 2, JAN 2021. (19/17685-2)

ZAIA, RACHEL; QUINTO, GIOVANNA M.; CAMARGO, LIVIA C. S.; RIBEIRO, RODRIGO T.; CARMONA-RIBEIRO, ANA M.. Transient Coatings from Nanoparticles Achieving Broad-Spectrum and High Antimicrobial Performance. PHARMACEUTICALS, v. 16, n. 6, p. 15-pg., 2023-06-01. (19/17685-2)

PEREZ-BETANCOURT, YUNYS; ZAIA, RACHEL; EVANGELISTA, MARINA FRANCHI; RIBEIRO, RODRIGO TADEU; RONCOLETA, BRUNO MURILLO; MATHIAZZI, BEATRIZ IDERIHA; CARMONA-RIBEIRO, ANA MARIA. Characterization and Differential Cytotoxicity of Gramicidin Nanoparticles Combined with Cationic Polymer or Lipid Bilayer. PHARMACEUTICS, v. 14, n. 10, p. 18-pg., 2022-10-01. (19/17685-2)

CARMONA-RIBEIRO, ANA MARIA; PEREZ-BETANCOURT, YUNYS. Cationic Nanostructures for Vaccines Design. BIOMIMETICS, v. 5, n. 3, p. 47-pg., 2020-09-01. (19/17685-2)

PEREZ-BETANCOURT, YUNYS; ARAUJO, PERICLES MARQUES; LINS FERNANDES TAVORA, BIANCA DE CARVALHO; PEREIRA, DANIELE RODRIGUES; FAQUIM-MAURO, ELIANA LIMA; CARMONA-RIBEIRO, ANA MARIA. Cationic and Biocompatible Polymer/Lipid Nanoparticles as Immunoadjuvants. PHARMACEUTICS, v. 13, n. 11, NOV 2021. (19/17685-2, 19/17625-0)