Bioactive compounds of Brazilian red propolis on periodontal disease

• Grant number: 19/19691-0
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2020
• End date: March 31, 2024
• Field of knowledge: Health Sciences - Dentistry - Social and Preventive Dentistry
• Principal Investigator: Bruno Bueno Silva
• Grantee: Bruno Bueno Silva
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
• Associated researchers: Daniele Ribeiro de Araujo ; Magda Feres Figueiredo ; Poliana Mendes Duarte
• Associated research grant(s): 25/02096-2 - 2025 IADR/PER General Session & Exhibition, AR.EXT

Abstract

Several diseases are characterized by an exacerbated inflammatory response, standing out periodontitis, that presents high global prevalence. In this way, the search for new immunomodulatory molecules is intense in the literature and the natural products stand out in this area. Among these molecules, neovestitol and vestitol presented anti-inflammatory and antimicrobial properties in vitro, however, there are no reports in the literature about treatment of periodontitis through in vivo models using these compounds. Thus, it has been hypothesized that neovestitol and vestitol have potential as an adjuvant in the treatment of periodontitis. Recently, combination of neovestitol/vestitol (CNV) presented anti-caries and was effective on atherosclerosis treatment through different in vivo models. In addition, it has recently been demonstrated that despite the numerous in vitro studies with natural products, few studies in the dental area have created the conditions for future clinical studies with natural products. Therefore, the objective of the present project is to evaluate the effects of CNV on periodontitis (in different formulations) elucidating its mechanisms of action through the following methodologies: 1- subgingival biofilm related to periodontitis; 2-in vivo models of periodontitis with posterior ELISA and PCR to elucidate the CNV mechanisms. With this proposal, it is expected to demonstrate the pharmacological activity of the compounds through the in vitro and in vivo models, and thus create subsidies for a future clinical study besides obtaining a patent(s) of use of the compound(s). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MACEDO, TATIANE TIEMI; MALAVAZI, LARISSA MATIAS; VARGAS, GUSTAVO QUILLES; GONCALVES, FRANCISCO JERFESON DOS SANTOS; GOMES, ALINE PAIM DE ABREU PAULO; BUENO, MANUELA ROCHA; AGUIAR DA SILVA, LUCAS DAYLOR; FIGUEIREDO, LUCIENE CRISTINA; BUENO-SILVA, BRUNO. Combination of Neovestitol and Vestitol Modifies the Profile of Periodontitis-Related Subgingival Multispecies Biofilm. BIOMEDICINES, v. 12, n. 6, p. 9-pg., 2024-06-01. (17/16377-7, 19/19691-0)