Use of antidepressants by adults: prevalence and trends in national and local consumption

• Grant number: 20/14960-0
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2021
• End date: October 31, 2023
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Tais Freire Galvao
• Grantee: Tais Freire Galvao
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Fernanda Inês de Carvalho Pereira Ribeiro Vaz ; Marcus Tolentino Silva
• Associated scholarship(s): 22/13611-7 - Use of antidepressants by adults: prevalence and national and local consumption trends, BP.TT

Abstract

Three different researches will be conducted to investigate the use of antidepressants in Brazil: a cross-sectional population-based study with adults living in Manaus, a systematic review with meta-analysis of drug utilization studies on the use of antidepressants in Brazil and a time series analysis of data related to antidepressants sales in Brazil between 2014 and 2019. In the cross-sectional study, participants were selected by probabilistic sampling in three stages and interviewed in their homes in 2019. The consumption of medicines in the last 15 days was investigated and from them, the antidepressants will be identified based on the Anatomical Therapeutic Chemical Classification System classification of the World Health Organization. Poisson regression with robust variance will be used to assess the prevalence ratios of antidepressant use. The systematic review will be conducted from searches on bibliographic indexing databases, with no date or language restrictions. The selection of studies, data extraction, and assessment of the quality of the primary studies will be performed by two independent researchers. The prevalence of antidepressant use reported in individual studies will be combined through meta-analysis. The trends in the consumption of antidepressants in Brazil from 2014 to 2019 will be investigated by analyzing the database of the Sistema Nacional de Gerenciamento de Produtos Controlados, which contains sales data of drugs subject to special control. The consumption of antidepressants will be converted into the defined daily dose (DDD) and the DDD for every 1,000 inhabitants per municipality will be calculated, according to population estimates in each year. Associations with local indicators will be conducted in ecological analyzes. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GUSTAVO MAGNO BALDIN TIGUMAN; MARCUS TOLENTINO SILVA; TAÍS FREIRE GALVÃO. Prevalência de uso de psicotrópicos e antidepressivos em uma cidade da Amazônia brasileira: análise de dois estudos transversais. Ciênc. saúde coletiva, v. 28, n. 1, p. 83-92, 2023-01-06. (20/14960-0)

HOEFLER, ROGERIO; BALDIN TIGUMAN, GUSTAVO MAGNO; GALVAO, TAIS FREIRE; RIBEIRO-VAZ, INES; SILVA, MARCUS TOLENTINO. Trends in sales of antidepressants in Brazil from 2014 to 2020: A time trend analysis with joinpoint regression. Journal of Affective Disorders, v. 323, p. 6-pg., 2023-02-15. (20/14960-0)

GUSTAVO MAGNO BALDIN TIGUMAN; ROGÉRIO HOEFLER; MARCUS TOLENTINO SILVA; VANESSA GOMES LIMA; INÊS RIBEIRO-VAZ; TAÍS FREIRE GALVÃO. Prevalence of antidepressant use in Brazil: a systematic review with meta-analysis. Revista Brasileira de Psiquiatria, v. 46, 2024-04-26. (20/14960-0)