Improvement and design of cathonic peptidic sequences with antitumoral and antibacterial action

• Grant number: 19/27135-0
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2021
• End date: March 31, 2023
• Field of knowledge: Biological Sciences - Biophysics - Molecular Biophysics
• Principal Investigator: Manoel de Arcisio Miranda Filho
• Grantee: Manoel de Arcisio Miranda Filho
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Danilo Roman Campos ; Fernando Augusto de Oliveira Ribeiro

Abstract

This project aims to design new cationic peptide sequences with selective action against cancer cells and bacteria. With a multidisciplinary approach, the present project proposal will allow, besides the determination of structural aspects of the studied peptides, to simultaneously obtain temporal and spatial resolution of the mechanisms involved in the action of cationic peptides in cells. Three major aspects will be studied: 1) the relationship between hydrophobic moment of cationic peptides and anticancer and antimicrobial action; 2) design of peptide sequences from alpha helix segments of classical ion channels; and 3) the relationship between extracellular agents such as glycosaminoglycans and anticancer action. (AU)