Thermoanalytical studies applied to antihepatitis and antiretroviral drugs of the protease inhibitor class: thermal behavior, decomposition intermediates, volatile characterization and polymorphism

• Grant number: 19/22217-8
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2021
• End date: September 30, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Éder Tadeu Gomes Cavalheiro
• Grantee: Éder Tadeu Gomes Cavalheiro
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated researchers: Carla Cristina Schmitt Cavalheiro ; Gilbert Bannach ; Rosa Lucia Simencio Otero

Abstract

In the form of epidemics, viral infections represent a serious public health problem, but when they take on the proportions of pandemics, they also affect social and economic aspects on a global scale, as at the moment in which we live. In this project, it is intended to contribute to the thermoanalytical studies of antiviral drugs used to fight infections by HIV and hepatitis viruses. It has been a latent idea in our group for some years now, which is becoming more important in view of the serious problems caused by these infectious agents and the great difficulty in developing vaccines for prevention and efficient drugs for the treatment of diseases caused by viruses. Thus, a relatively long introduction is presented, but necessary to contextualize the problem involved and the difficulties of obtaining efficient antiviral agents, for which it is necessary to understand what viruses are, how they act, how they replicate and how they infect healthy cells. Associated with complementary techniques, thermonalitic results can contribute significantly to the characterization and understanding of the behavior of drugs, including studies (a) identification and characterization: determination of the melting point, phase changes, glass transitions and moisture content and control Of Quality; b) Stability: thermal decomposition, kinetic analysis of decomposition, c) Polymorphism and pseudo-polymorphism; d) Purity; (e) Phase diagrams; f) Quantification and detection. Chromatographic methods, although useful in the quantification and separation of components of formulations, do not allow assessing stability, nor to characterize mechanisms of drug decomposition. Thus, the separation techniques associated with the thermoanalytical methods offer a wide range of characterization and quality control of these substances. Thus, this project aims to contribute to the study of antiviral drugs of the protease inhibitor class, which can be divided between those used in the treatment of HIV and in the treatment of hepatitis. Interestingly, there are few thermoanalytical studies of these drugs, despite their enormous importance for contemporary society. As a result of these studies, it is expected to obtain complete mechanisms for the behavior of these drugs, including characterization of decomposition intermediates and substances evolved during thermal decomposition, detection of possible polymorphs, phase transitions and other relevant information, using spectroscopic techniques (FTIR, NMR, HPLC-MS, etc.), microscopy (optics and thermomicroscopy) and others. This is intended to contribute to the development aspects of these drugs and to the problems of drug resistance and disposal. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE ARRUDA SILVA, JOAO VITOR; CAVALHEIRO, EDER T. G.; CERVINI, PRISCILA. Graphite-polyurethane composite electrode modified with nickel(II) nanoparticles submitted to electrochemical pretreatment in basic medium for the determination of atenolol. Analytical Letters, v. N/A, p. 16-pg., 2023-04-19. (19/22217-8)

DE FREITAS, JONATHA; FERREIRA, ANA PAULA GARCIA; CAVALHEIRO, EDER TADEU GOMES. Thermal analysis of tetracyclines: a review. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. N/A, p. 13-pg., 2023-06-24. (19/22217-8)

RAFAEL DA SILVA; PRISCILA CERVINI; ÉDER T. G. CAVALHEIRO. A Simple and Sensitive Non Modified Acetylene Black-Polyurethane Composite Electrode in the Determination of Bisphenol-A in Water Samples. Journal of the Brazilian Chemical Society, v. 35, n. 5, 2024-02-26. (19/22217-8)