| Grant number: | 21/04429-8 |
| Support Opportunities: | Regular Research Grants |
| Start date: | November 01, 2021 |
| End date: | October 31, 2022 |
| Field of knowledge: | Health Sciences - Medicine - Surgery |
| Principal Investigator: | Fausto Viterbo de Oliveira Neto |
| Grantee: | Fausto Viterbo de Oliveira Neto |
| Host Institution: | Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
| Associated researchers: | José de Anchieta de Castro e Horta Júnior ; Marco Antônio Zanini |
Abstract
Front 1: In plastic surgery, many free flaps develop thrombosis in the postoperative period and need to be re-approached. Therefore, we think that the excesses of discarded pedicles, especially arterial ones, could be buried in the subcutaneous tissue and, if necessary, used as grafts, which would reduce the complications of obtaining new vascular grafts. Thus, we want to evaluate the feasibility of creating a bank of autologous vascular grafts under the skin for later use and to analyze possible degenerations that occur during the period of accommodation. Front 2:The implantation of a peripheral nerve graft in the central nervous system (CNS), if possible, would open numerous paths for the treatment of diseases, currently without cure. In the 1980s and 90s, some researchers, such as Aguayo, Benfey and Morrow, performed peripheral nerve grafts implanted in the CNS - spinal cord, brain and thalamus - achieving positive results, with axonal growth and conduction of electrical current, although there was no evidence that they were able to perform synapses. The aforementioned studies are relevant because they sought, through SNP grafts in the CNS, to analyze the viability of regenerating damaged neurons and axonal growth. However, no experiment was found in the literature in which one end of a peripheral nerve graft was placed in the subcutaneous tissue, fixed to the periosteum, and the other inserted in the cerebral parenchyma. Thus, the focus of the present study will be to analyze the viability of axonal regeneration from brain tissue in a peripheral nerve graft, taking these axons out of the skull. The doubt about the occurrence of this axonal regeneration led us to carry out this experiment. Front 3:The risk of peripheral nerve damage related to medical procedures is real, especially due to needles in injections or nerve blocks and also the needles in the sutures. The injury can result from stretching, compacting, hypoperfusion, direct trauma or exposure of the nerve to neuro-toxic substances. However, little is known if the simple penetration of the needle into the nerve would determine an injury; or whether the intra-neural injection of different substances, such as saline (0.9% NaCl) and Lidocaine, would present different levels of lesions. To better understand the trauma due to needles or injections, we decided to do this work. (AU)
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