Brewery waste biorefinery to obtain biologically active substances for prevention and treatment of SARS-CoV-2 and for its use as natural food preservatives

• Grant number: 21/15138-4
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: May 01, 2022
• End date: April 30, 2023
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Ricardo Pinheiro de Souza Oliveira
• Grantee: Ricardo Pinheiro de Souza Oliveira
• Visiting researcher: Jose Manuel Dominguez Gonzalez
• Visiting researcher institution: Universidade de Vigo, Spain
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 18/25511-1 - Bioprospecting of bacteriocin-producing bacteria: from culture optimization to the application in animal production systems, AP.TEM

Abstract

The work plan will be developed jointly between the groups of Prof. Dr. RICARDO PINHEIRO DE SOUZA OLIVEIRA from the Faculty of Pharmaceutical Sciences at USP - São Paulo Unit, and the Visiting Researcher, Prof. JOSÉ MANUEL DOMÍNGUEZ GONZÁLEZ, Professor at the Department of Chemical Engineering at the University of Vigo - Spain. Both professors have previously collaborated on numerous projects, which has resulted in numerous joint publications, as described below. It should be noted that subprojects 4 and 6 are partially part of the project "Bioprospecting bacteriocinogenic probiotic bacteria: from optimization of cultivation to application in animal production systems", Process Number: 2018/25511-1, funded by the Research Support Foundation of the State of São Paulo (FAPESP) and led by Prof. Ricardo Pinheiro de Souza Oliveira, in which the Visiting Researcher collaborates. More recently, prof. Ricardo submitted the proposal for the CNPq Universal 18/2021 notice, again with the participation of Prof. Dominguez. Thus, the visiting researcher has actively participated in the elaboration of these projects, and during their stay the results obtained so far will be discussed, while new objectives and planned subprojects will be developed. Based on these results, a minimum of six articles will be prepared, as well as new project directions will be defined.It should be noted that this project presents a new line of research, aimed at studying the inhibition of the SARS-CoV-2 Mpro enzyme with polyphenols previously recovered from beer bagasse, which intends to be a small contribution to the scientific need to help overcome the global pandemic caused by the SARS-CoV-2 Virus. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MENDONCA, CARLOS M. N.; OLIVEIRA, RODRIGO C.; PIZAURO, LUCAS J. L.; PEREIRA, WELLISON A.; ABBOUD, KAHLILE; ALMEIDA, SONIA; WATANABE, II-SEI; VARANI, ALESSANDRO M.; DOMINGUEZ, JOSE M.; CORREA, BENEDITO; et al. Tracking new insights into antifungal and anti-mycotoxigenic properties of a biofilm forming Pediococcus pentosaceus strain isolated from grain silage. International Journal of Food Microbiology, v. 405, p. 10-pg., 2023-11-16. (18/25511-1, 20/13271-6, 21/15138-4)

GUADALUPE MORAN-AGUILAR, MARIA; CALDERON-SANTOYO, MONTSERRAT; DE SOUZA OLIVEIRA, RICARDO PINHEIRO; GUADALUPE AGUILAR-USCANGA, MARIA; MANUEL DOMINGUEZ, JOSE. Deconstructing sugarcane bagasse lignocellulose by acid-based deep eutectic solvents to enhance enzymatic digestibility. Carbohydrate Polymers, v. 298, p. 8-pg., 2022-12-15. (18/25511-1, 21/15138-4)

OUTEIRINO, DAVID; COSTA-TRIGO, IVAN; DE SOUZA OLIVEIRA, RICARDO PINHEIRO; GUERRA, NELSON PEREZ; SALGADO, JOSE MANUEL; DOMINGUEZ, JOSE MANUEL. Biorefinery of Brewery Spent Grain by Solid-State Fermentation and Ionic Liquids. FOODS, v. 11, n. 22, p. 14-pg., 2022-11-01. (21/15138-4)

COSTA-TRIGO, IVAN; PAZ, ALICIA; MORAN-AGUILAR, MARIA GUADALUPE; GUERRA, NELSON PEREZ; OLIVEIRA, RICARDO PINHEIRO DE SOUZA; DOMINGUEZ, JOSE MANUEL. Enhancing the biorefinery of chestnut burrs. Part I. Study of the pretreatment with choline chloride urea diluted deep eutectic solvent. BIOMASS & BIOENERGY, v. 173, p. 9-pg., 2023-06-01. (18/25511-1, 21/15138-4)