WFDC1 - Role in cardiovascular system development and potential applications in translational medicine

• Grant number: 22/03880-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2022
• End date: July 31, 2024
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Agreement: Monash University
• Principal Investigator: Hernandes Faustino de Carvalho
• Grantee: Hernandes Faustino de Carvalho
• Principal researcher abroad: Gonzalo del Monte Nieto
• Institution abroad: Monash University, Australia
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Lúcia Elvira Álvares
• Associated research grant: 21/02303-7 - Single cell analyses and non-linear optics approaches of prostate biology, AP.TEM

Abstract

WFDC1 is a highly conserved ancient gene encoding a small, secreted protein present in the extracellular matrix with critical roles in angiogenesis, cancer, immune response, and tissue repair. WFDC1 upregulation has been associated with changes in endothelial biomarkers, cardiac hypertrophy and cardiac failure. However, its specific role during normal cardiovascular development, adult homeostasis and disease is still unknown. This project aims to investigate WFDC1 functions in cardiovascular development and disease by integrating Developmental and Systems Biology approaches in different model organisms and in vitro systems. The project outcomes will have a significant impact in discovering new genes causing cardiovascular disease. (AU)