Research Grants 22/03880-0 - Pesquisa médica translacional, Biologia celular - BV FAPESP
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WFDC1 - Role in cardiovascular system development and potential applications in translational medicine

Grant number: 22/03880-0
Support Opportunities:Regular Research Grants
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Agreement: Monash University
Principal Investigator:Hernandes Faustino de Carvalho
Grantee:Hernandes Faustino de Carvalho
Principal researcher abroad: Gonzalo del Monte Nieto
Institution abroad: Monash University, Australia
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers:Lúcia Elvira Álvares
Associated research grant:21/02303-7 - Single cell analyses and non-linear optics approaches of prostate biology, AP.TEM

Abstract

WFDC1 is a highly conserved ancient gene encoding a small, secreted protein present in the extracellular matrix with critical roles in angiogenesis, cancer, immune response, and tissue repair. WFDC1 upregulation has been associated with changes in endothelial biomarkers, cardiac hypertrophy and cardiac failure. However, its specific role during normal cardiovascular development, adult homeostasis and disease is still unknown. This project aims to investigate WFDC1 functions in cardiovascular development and disease by integrating Developmental and Systems Biology approaches in different model organisms and in vitro systems. The project outcomes will have a significant impact in discovering new genes causing cardiovascular disease. (AU)

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