Safety and efficacy test of anti-aging dog food

• Grant number: 22/14528-6
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: September 01, 2023
• End date: May 31, 2024
• Field of knowledge: Health Sciences - Nutrition
• Principal Investigator: Silas Pinto da Silva
• Grantee: Silas Pinto da Silva
• Company: Silas Pinto da Silva
• CNAE: Pesquisa e desenvolvimento experimental em ciências físicas e naturais
• Pesquisadores principais: Diogo de Moraes
• Associated scholarship(s): 23/12395-1 - Safety and efficacy test of anti-aging dog food, BP.PIPE

Abstract

The world market for pet products has been growing surprisingly in recent years. Recent estimates show that the demand for tutoring animals through adoption has increased by more than 50% in the last 2 years, with almost 20% of these adoptions being carried out by families that did not yet live with pets. According to Instituto Pet Brasil, the general pet market grew 30% in the same period. According to the latest AbinPet report, this market moves around 35 billion reais annually in Brazil alone and, among the related sectors, the food sector stands out for accounting for 79% of the total Brazilian market, in addition to being the one that grew the most in the cycle 2020/2021. Also, according to AbinPet, Brazil has approximately 150 million pets, with a dog population of almost 60 million. In addition, the market with the highest concentration is in the Southeast region, where almost half of the total population of Brazilian pets lives. Fortunately, in addition to looking for animals to give and receive company, following the food sector, the veterinary care and general care sectors are also growing, showing the care that tutors have with animals. This concern for the health of the animal brings numerous benefits to pets, and the trend is that the number of elderly animals will grow significantly in the coming years. Unfortunately, like humans, with aging, companion animals also have health problems that gradually reduce their quality of life. Aging is a multifactorial process consisting of a decline in cellular functions that, over the years, leads to a decline in the function of multiple organs and, ultimately, to death. There are now numerous attempts to reduce the impact of aging on various species. Emerging as a central agent in the aging process is the appearance and accumulation of senescent cells. These cells, in addition to being incapable of dividing and presenting several functional changes, send molecular signals to other cells, causing the senescence process to be propagated and may result in inflammation and fibrosis. The use of senolytics, compounds that eliminate senescent cells, has been shown to be a very efficient tool in the fight against aging-related diseases. Studies in different species have shown that periodic treatment with this type of compound reduces inflammation, increases antioxidant defense, reduces the appearance of cancer, improves physical conditioning and increases lifespan. There is great interest in the pharmaceutical development of products based on senolytics, including for the treatment of humans, which can be seen by the variety of clinical trials that are currently being carried out. The pet market is also very interested in compounds that can be used to prevent disease and fight aging. We therefore present, in this proposal, a feed containing the senolytic fisetin, for administration of dogs that seeks to prevent and combat the appearance and accumulation of senescent cells, ensuring health and well-being for these animals. (AU)