IMPACT OF DIFFERENT STAGES OF HEART FAILURE ON METABOLOMIC PROFILE, CIRCULATING ENDOGENOUS BIOGENIC AMINES LEVELS AND CLINICAL-NUTRITIONAL PARAMETERS

• Grant number: 23/08537-5
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2023
• End date: October 31, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Silméia Garcia Zanati Bazan
• Grantee: Silméia Garcia Zanati Bazan
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Artur Junio Togneri Ferron ; Camila Renata Corrêa ; Fabiane Valentini Francisqueti Ferron ; Giuseppina Pace Pereira Lima
• Associated scholarship(s): 24/15718-9 - Association among nutritional status, echocardiographic parameters and circulating endogenous biogenic amines in patients with heart failure, BP.IC

Abstract

Heart failure (HF) is defined as the heart inability to supply peripheral tissues with the necessary blood and oxygen amount for metabolic demands, leading to a clinical syndrome characterized by symptoms such as dyspnea or fatigue, and signs such as elevated jugular venous pressure, tachycardia or peripheral edema. The literature reports that disease progression is associated with increased congestion, oxidative stress, inflammation and metabolic changes, whose mechanisms involved are not fully elucidated. Amines are essential molecules for normal cell growth and function. Changes in its levels seem to be associated with cardiac hypertrophy and remodeling and cachexia/sarcopenia, demonstrated by in vivo and experimental studies. However, there are several gaps regarding the relationship between amines and cardiac and clinical-nutritional parameters. The aim will be to investigate the impact of different degrees of CI on the metabolomic profile, levels of circulating endogenous biogenic amines and clinical-nutritional parameters. Cross-sectional study to be carried out with patients being followed up at the Cardiology outpatient clinic of the Hospital das Clínicas of the Faculdade de Medicina de Botucatu-UNESP, already approved by the Institution's Ethics Committee. Clinical and nutritional information will be collected from patients. Plasma levels of amines and the metabolomic profile of patients will be evaluated. The variables will be submitted to descriptive and comparative analysis by specific tests according to their behavior. (AU)