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EVALUATION OF PHOTODYNAMIC THERAPY WITH DIFFERENT COMPOUNDS FOR MICROBIAL INACTIVATION - IN VITRO AND IN VIVO ASSAYS

Grant number: 22/10251-0
Support Opportunities:Regular Research Grants
Duration: November 01, 2023 - October 31, 2025
Field of knowledge:Biological Sciences - Biophysics - Radiology and Photobiology
Principal Investigator:Juliana Guerra Pinto
Grantee:Juliana Guerra Pinto
Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
Associated researchers: ALEJANDRO GUILLERMO MIÑAN ; Andreza Ribeiro Simioni ; Isabelle Ferreira ; Juliana Ferreira Strixino ; Kumiko Koibuchi Sakane ; Martha Simões Ribeiro ; SALVATORE SORTINO

Abstract

Bacteria are important in several biological processes, as well as used in industrial and physiological processes. The human skin is the largest organ in our body, responsible for the protection of the internal environment and the interaction of the organism with the environment. Bacteria are found in large quantities in our gastrointestinal tract and oral cavity, for example, in addition to colonizing our skin, constituting the human microbiota. The microbiota plays a crucial role in the protection that our skin provides to the body, helping to maintain skin acidity and preventing colonization by pathogenic microorganisms. However, the ability of bacteria to develop resistance to antibiotics becomes the biggest threat to human health in the 21st century, with estimates of 10 million deaths from resistance by 2050. Infections with resistant bacteria increase a patient's hospital stay, increase the expenses and increase the risk of death. The need for alternative therapies capable of eliminating microorganisms without creating resistance is a reality. PDT has shown promising results in the treatment of various lesions and bacterial inactivation. The present project aims to evaluate the cytotoxicity of curcumin encapsulated in anionic and cationic bovine serum albumin (BSA) nanoparticles and Nitric Oxide Photodonor Rhodamine in clinical strains of Staphylococcus aureus and Pseudomonas aeruginosa, in vitro, and to evaluate the effect of PDT with different formulations of nanoencapsulated curcumin and Nitric Oxide Photo Donor compound in lesions infected with S. aureus and P. aeruginosa in vivo. (AU)

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