The role of celular prion protein in physiological and pathological processes II

• Grant number: 03/13189-2
• Support Opportunities: Research Projects - Thematic Grants
• Start date: July 01, 2004
• End date: April 30, 2009
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Vilma Regina Martins
• Grantee: Vilma Regina Martins
• Host Institution: Instituto Ludwig de Pesquisa sobre o Câncer (ILPC). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated research grant(s): 06/50942-9 - Involvment of cellular prion-stress inducible protein 1 interaction in neural plasticity mechanisms: neuritogenesis, neuroprotection and memory consolidation., AR.EXT; 06/52103-4 - Different ca2+ signaling pathways mediated by cellular prion protein interaction to laminin gama-1 peptide or stress-inducible protein 1., AR.EXT

Abstract

The cellular prion protein has been receiving a lot of evidence in the literature not only because its involvement in prion diseases but also due to is biological relevance. Through it is important to note that our group is giving an important contribution in this last aspect. In our previous project we characterized 3 PrPc ligands: laminin and vitronectin at the extracellular matrix and STI1 at the cell surface. The cellular functions related with these interactions and part of the triggered cell signaling were also determined. These results point to a PrPc pleiotropic function probably through a macromolecular complex formed with its ligands. An important result obtained in our last project was the tinding of arare polymorphism at PRNP which is present in 23% of patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS). Furthermore, patients with MTLE-HS showing this variant alIele had five fold greater chance of remaining intractable after temporal lobectomy. Thus, our results point to many events that must be approached in arder to map all the biological functions related to the celIular prion protein… (AU)

Scientific publications

(14)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

SANTOS, TIAGO G.; SILVA, IARA R.; COSTA-SILVA, BRUNO; LEPIQUE, ANA PAULA; MARTINS, VILMA R.; LOPES, MARILENE H.. Enhanced Neural Progenitor/Stem Cells Self-Renewal via the Interaction of Stress-Inducible Protein 1 with the Prion Protein. Stem Cells, v. 29, n. 7, p. 1126-1136, JUL 2011. (03/13189-2, 07/08410-2, 09/14027-2)

LOPES, MARILENE H.; HAJJ, GLAUCIA N. M.; MURAS, ANGELITA G.; MANCINI, GABRIEL L.; CASTRO, ROSA M. P. S.; RIBEIRO, KARINA C. B.; BRENTANI, RICARDO R.; LINDEN, RAFAEL; MARTINS, VILMA R.. Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways. JOURNAL OF NEUROSCIENCE, v. 25, n. 49, p. 11330-11339, Dec. 2005. (03/13189-2)

LIMA, FLAVIA R. S.; ARANTES, CAMILA P.; MURAS, ANGELITA G.; NOMIZO, REGINA; BRENTANI, RICARDO R.; MARTINS, VILMA R.. Cellular prion protein expression in astrocytes modulates neuronal survival and differentiation. Journal of Neurochemistry, v. 103, n. 6, p. 2164-2176, Dec. 2007. (03/13189-2)

ERLICH, RAFAEL B.; KAHN, SUZANA A.; LIMA, FLÁVIA R. S.; MURAS, ANGELITA G.; MARTINS, RODRIGO A. P.; LINDEN, RAFAEL; CHIARINI, LUCIANA B.; MARTINS, VILMA R.; MOURA NETO, VIVALDO. STI1 promotes glioma proliferation through AUPK and PI3K pathways. Glia, v. 55, n. 16, p. 1690-1698, Dec. 2007. (03/13189-2)

LOBÃO-SOARES‚ B.; BIANCHIN‚ M.M.; LINHARES‚ M.N.; CARQUEJA‚ C.L.; TASCA‚ C.I.; SOUZA‚ M.; MARQUES‚ W.; BRENTANI‚ R.; MARTINS‚ V.R.; SAKAMOTO‚ A.C.; et al. Normal brain mitochondrial respiration in adult mice lacking cellular prion protein. Neuroscience Letters, v. 375, n. 3, p. 203-206, 2005. (99/07124-8, 03/13189-2)

NICO‚ P.B.C.; LOBÃO-SOARES‚ B.; LANDEMBERGER‚ M.C.; MARQUES‚ W.; TASCA‚ C.I.; DE MELLO‚ C.F.; WALZ‚ R.; CARLOTTI‚ C.G.; BRENTANI‚ R.R.; SAKAMOTO‚ A.C.; et al. Impaired exercise capacity‚ but unaltered mitochondrial respiration in skeletal or cardiac muscle of mice lacking cellular prion protein. Neuroscience Letters, v. 388, n. 1, p. 21-26, 2005. (03/13189-2)

LOBÃO-SOARES‚ B.; WALZ‚ R.; CARLOTTI JR‚ C.G.; SAKAMOTO‚ A.C.; CALVO‚ F.; TERZIAN‚ A.L.B.; SILVA‚ J.A.; WICHERT-ANA‚ L.; COIMBRA‚ N.C.; BIANCHIN‚ M.M.. Cellular prion protein regulates the motor behaviour performance and anxiety-induced responses in genetically modified mice. Behavioural Brain Research, v. 183, n. 1, p. 87-94, 2007. (03/13189-2)

MEOTTI‚ F.C.; CARQUEJA‚ C.L.; GADOTTI‚ V.M.; TASCA‚ C.I.; WALZ‚ R.; SANTOS‚ A.R.S.. Involvement of cellular prion protein in the nociceptive response in mice. Brain Research, v. 1151, p. 84-90, 2007. (03/13189-2)

MAGLIO‚ L.E.; MARTINS‚ V.R.; IZQUIERDO‚ I.; RAMIREZ‚ O.A.. Role of cellular prion protein on LTP expression in aged mice. Brain Research, v. 1097, n. 1, p. 11-18, 2006. (03/13189-2)

NICO‚ P.B.C.; DE-PARIS‚ F.; VINADÉ‚ E.R.; AMARAL‚ O.B.; ROCKENBACH‚ I.; SOARES‚ B.L.; GUARNIERI‚ R.; WICHERT-ANA‚ L.; CALVO‚ F.; WALZ‚ R.; et al. Altered behavioural response to acute stress in mice lacking cellular prion protein. Behavioural Brain Research, v. 162, n. 2, p. 173-181, 2005. (03/13189-2)

ROMANO, SEBASTIAN A.; CORDEIRO, YRAIMA; LIMA, LUIS MAURICIO T. R.; LOPES, MARILENE H.; SILVA, JERSON L.; FOGUEL, DEBORA; LINDEN, RAFAEL. Reciprocal remodeling upon binding of the prion protein to its signaling partner hop/STI1. FASEB JOURNAL, v. 23, n. 12, p. 4308-4316, DEC 2009. (03/13189-2)

ARANTES, CAMILA; NOMIZ, REGINA; LOPES, MARILENE H.; HAJJ, GLAUCIA N. M.; LIMA, FLAVIA R. S.; MARTINS, VILMA R.. Prion Protein and Its Ligand Stress Inducible Protein 1 Regulate Astrocyte Development. Glia, v. 57, n. 13, p. 1439-1449, OCT 2009. (03/13189-2)

COITINHO, ADRIANA S.; LOPES, MARILENE H.; HAJJ, GLAUCIA N. M.; ROSSATO, JANINE I.; FREITAS, ADRIANA R.; CASTRO, CIBELE C.; CAMMAROTA, MARTIN; BRENTANI, RICARDO R.; IZQUIERDO, IVAN; MARTINS, VILMA R.. Short-term memory formation and long-term memory consolidation are enhanced by cellular prion association to stress-inducible protein 1. Neurobiology of Disease, v. 26, n. 1, p. 282-290, Apr. 2007. (03/13189-2)

COIMBRA‚ É.R.; REZEK‚ K.; ESCORSI-ROSSET‚ S.; LANDEMBERGER‚ M.C.; CASTRO‚ R.M.; VALADÃO‚ M.N.; GUARNIERI‚ R.; VELASCO‚ T.R.; TERRA-BUSTAMANTE‚ V.C.; BIANCHIN‚ M.M.; et al. Cognitive performance of patients with mesial temporal lobe epilepsy is not associated with human prion protein gene variant allele at codons 129 and 171. Epilepsy & Behavior, v. 8, n. 3, p. 635-642, 2006. (03/13189-2)