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The role of celular prion protein in physiological and pathological processes II

Grant number: 03/13189-2
Support type:Research Projects - Thematic Grants
Duration: July 01, 2004 - April 30, 2009
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Vilma Regina Martins
Grantee:Vilma Regina Martins
Home Institution: Instituto Ludwig de Pesquisa sobre o Câncer (ILPC). São Paulo , SP, Brazil
Associated grant(s):06/50942-9 - Involvement of cellular prion-stress inducible protein 1 interaction in neural plasticity mechanisms: neuritogenesis, neuroprotection and memory consolidation, AR.EXT
06/52103-4 - Different Ca2+ signaling pathways mediated by cellular prion protein interaction to laminin gama-1 peptide or Stress-inducible protein 1, AR.EXT


The cellular prion protein has been receiving a lot of evidence in the literature not only because its involvement in prion diseases but also due to is biological relevance. Through it is important to note that our group is giving an important contribution in this last aspect. In our previous project we characterized 3 PrPc ligands: laminin and vitronectin at the extracellular matrix and STI1 at the cell surface. The cellular functions related with these interactions and part of the triggered cell signaling were also determined. These results point to a PrPc pleiotropic function probably through a macromolecular complex formed with its ligands. An important result obtained in our last project was the tinding of arare polymorphism at PRNP which is present in 23% of patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS). Furthermore, patients with MTLE-HS showing this variant alIele had five fold greater chance of remaining intractable after temporal lobectomy. Thus, our results point to many events that must be approached in arder to map all the biological functions related to the celIular prion protein… (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Gatekeeper to the cells 

Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, TIAGO G.; SILVA, IARA R.; COSTA-SILVA, BRUNO; LEPIQUE, ANA PAULA; MARTINS, VILMA R.; LOPES, MARILENE H. Enhanced Neural Progenitor/Stem Cells Self-Renewal via the Interaction of Stress-Inducible Protein 1 with the Prion Protein. Stem Cells, v. 29, n. 7, p. 1126-1136, JUL 2011. Web of Science Citations: 42.
ROMANO, SEBASTIAN A.; CORDEIRO, YRAIMA; LIMA, LUIS MAURICIO T. R.; LOPES, MARILENE H.; SILVA, JERSON L.; FOGUEL, DEBORA; LINDEN, RAFAEL. Reciprocal remodeling upon binding of the prion protein to its signaling partner hop/STI1. FASEB JOURNAL, v. 23, n. 12, p. 4308-4316, DEC 2009. Web of Science Citations: 15.
ARANTES, CAMILA; NOMIZ, REGINA; LOPES, MARILENE H.; HAJJ, GLAUCIA N. M.; LIMA, FLAVIA R. S.; MARTINS, VILMA R. Prion Protein and Its Ligand Stress Inducible Protein 1 Regulate Astrocyte Development. Glia, v. 57, n. 13, p. 1439-1449, OCT 2009. Web of Science Citations: 42.
ERLICH, RAFAEL B.; KAHN, SUZANA A.; LIMA, FLÁVIA R. S.; MURAS, ANGELITA G.; MARTINS, RODRIGO A. P.; LINDEN, RAFAEL; CHIARINI, LUCIANA B.; MARTINS, VILMA R.; MOURA NETO, VIVALDO. STI1 promotes glioma proliferation through AUPK and PI3K pathways. Glia, v. 55, n. 16, p. 1690-1698, Dec. 2007.
LIMA, FLAVIA R. S.; ARANTES, CAMILA P.; MURAS, ANGELITA G.; NOMIZO, REGINA; BRENTANI, RICARDO R.; MARTINS, VILMA R. Cellular prion protein expression in astrocytes modulates neuronal survival and differentiation. Journal of Neurochemistry, v. 103, n. 6, p. 2164-2176, Dec. 2007.
COITINHO, ADRIANA S.; LOPES, MARILENE H.; HAJJ, GLAUCIA N. M.; ROSSATO, JANINE I.; FREITAS, ADRIANA R.; CASTRO, CIBELE C.; CAMMAROTA, MARTIN; BRENTANI, RICARDO R.; IZQUIERDO, IVAN; MARTINS, VILMA R. Short-term memory formation and long-term memory consolidation are enhanced by cellular prion association to stress-inducible protein 1. Neurobiology of Disease, v. 26, n. 1, p. 282-290, Apr. 2007.
LOBÃO-SOARES‚ B.; WALZ‚ R.; CARLOTTI JR‚ C.G.; SAKAMOTO‚ A.C.; CALVO‚ F.; TERZIAN‚ A.L.B.; SILVA‚ J.A.; WICHERT-ANA‚ L.; COIMBRA‚ N.C.; BIANCHIN‚ M.M. Cellular prion protein regulates the motor behaviour performance and anxiety-induced responses in genetically modified mice. Behavioural Brain Research, v. 183, n. 1, p. 87-94, 2007.
MEOTTI‚ F.C.; CARQUEJA‚ C.L.; GADOTTI‚ V.M.; TASCA‚ C.I.; WALZ‚ R.; SANTOS‚ A.R.S. Involvement of cellular prion protein in the nociceptive response in mice. Brain Research, v. 1151, p. 84-90, 2007.
COIMBRA‚ É.R.; REZEK‚ K.; ESCORSI-ROSSET‚ S.; LANDEMBERGER‚ M.C.; CASTRO‚ R.M.; VALADÃO‚ M.N.; GUARNIERI‚ R.; VELASCO‚ T.R.; TERRA-BUSTAMANTE‚ V.C.; BIANCHIN‚ M.M.; OTHERS. Cognitive performance of patients with mesial temporal lobe epilepsy is not associated with human prion protein gene variant allele at codons 129 and 171. Epilepsy & Behavior, v. 8, n. 3, p. 635-642, 2006.
MAGLIO‚ L.E.; MARTINS‚ V.R.; IZQUIERDO‚ I.; RAMIREZ‚ O.A. Role of cellular prion protein on LTP expression in aged mice. Brain Research, v. 1097, n. 1, p. 11-18, 2006.
LOPES, MARILENE H.; HAJJ, GLAUCIA N. M.; MURAS, ANGELITA G.; MANCINI, GABRIEL L.; CASTRO, ROSA M. P. S.; RIBEIRO, KARINA C. B.; BRENTANI, RICARDO R.; LINDEN, RAFAEL; MARTINS, VILMA R. Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways. JOURNAL OF NEUROSCIENCE, v. 25, n. 49, p. 11330-11339, Dec. 2005.
LOBÃO-SOARES‚ B.; BIANCHIN‚ M.M.; LINHARES‚ M.N.; CARQUEJA‚ C.L.; TASCA‚ C.I.; SOUZA‚ M.; MARQUES‚ W.; BRENTANI‚ R.; MARTINS‚ V.R.; SAKAMOTO‚ A.C.; OTHERS. Normal brain mitochondrial respiration in adult mice lacking cellular prion protein. Neuroscience Letters, v. 375, n. 3, p. 203-206, 2005.
NICO‚ P.B.C.; DE-PARIS‚ F.; VINADÉ‚ E.R.; AMARAL‚ O.B.; ROCKENBACH‚ I.; SOARES‚ B.L.; GUARNIERI‚ R.; WICHERT-ANA‚ L.; CALVO‚ F.; WALZ‚ R.; OTHERS. Altered behavioural response to acute stress in mice lacking cellular prion protein. Behavioural Brain Research, v. 162, n. 2, p. 173-181, 2005.
NICO‚ P.B.C.; LOBÃO-SOARES‚ B.; LANDEMBERGER‚ M.C.; MARQUES‚ W.; TASCA‚ C.I.; DE MELLO‚ C.F.; WALZ‚ R.; CARLOTTI‚ C.G.; BRENTANI‚ R.R.; SAKAMOTO‚ A.C.; OTHERS. Impaired exercise capacity‚ but unaltered mitochondrial respiration in skeletal or cardiac muscle of mice lacking cellular prion protein. Neuroscience Letters, v. 388, n. 1, p. 21-26, 2005.

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