Ultra-Precision Machining and Two-Photon Lithography in the Fabrication of Micro- and Milli-reactors for the Synthesis of Chlorohydrin-Based Drugs

• Grant number: 23/12412-3
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2024
• End date: January 31, 2026
• Field of knowledge: Engineering - Chemical Engineering - Chemical Technology
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Mauri Sergio Alves Palma
• Grantee: Mauri Sergio Alves Palma
• Principal researcher abroad: Dirk Oberschmidt
• Institution abroad: Technical University of Berlin (TU), Germany
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Harrson Silva Santana
• Associated research grant: 22/16165-8 - Flow synthesis of Atenolol®, Metoprolol® and Ranolazine® using Glycerol derivatives as reactants, AP.R

Abstract

The synthesis of pharmaceutic drugs in flow has significant advantages over the usual batch process. The main reason is the high added value and low consumption of supplies during the synthesis of pharmaceutic drugs. Some advantages of drug synthesis in micro- and milli-reactors are the drastic reduction of reaction times due tothe elimination of inefficient mixing effects, increased yield, selectivity of reactions and reduced waste generation. Therefore, there is a great potential in expanding their synthesis in microreactors and millireactors. One of thecurrent methods of manufacturing millireactors and microreactors is through 3-D printing with a conventional 3-D printer. Such printing machines although useful in order to produce prototypes or print mock-ups of the microchannels are not precise enough for the required channels. Furthermore, the material of these reactors plays a crucial role on the application, since not all polymeric material withstands such elevated temperature and pressure during the synthesis process. Especially, considering the dimension requirements of the micro channels. (AU)