Search for etiological factors of dental enamel biomineralization defects: in vivo experimental study

• Grant number: 23/12014-8
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2024
• End date: June 30, 2026
• Field of knowledge: Health Sciences - Dentistry - Pediatric Dentistry
• Principal Investigator: Francisco Wanderley Garcia de Paula e Silva
• Grantee: Francisco Wanderley Garcia de Paula e Silva
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Alexandra Mussolino de Queiroz ; Fabrício Kitazono de Carvalho ; Guido Artemio Maranon Vasquez ; Maya Fernanda Manfrin Arnez

Abstract

Amelogenesis is the process of dental enamel formation, which is regulated by proteins and enzymes secreted by ameloblasts. Interruptions during amelogenesis can lead to failures in matrix secretion, resulting in enamel developmental defects. The etiological factors of enamel defects are widely unknown, but they are associated with systemic, genetic, and environmental factors that act during the gestational period and, mostly, in early years of life. Among environmental factors, exposure to toxic substances such as tobacco and toxic stress can cause numerous alterations in childhood development and may also be associated with enamel defects. Therefore, the aim of this study is to explore the exposure to adverse effects during infancy in rat pups and its impact on dental enamel biomineralization. Specifically, molecular effects on amelogenesis and the presence of morphological, quantitative, and qualitative alterations in fully erupted teeth will be assessed. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TARGINO DE SOUSA, JULIA INGRYD; GONCALVES, JULIANA DE LIMA; DE QUEIROZ, ALEXANDRA MUSSOLINO; DE CARVALHO, FABRICIO KITAZONO; GARCIA DE PAULA-SILVA, FRANCISCO WANDERLEY. Study protocol on the impact of postnatal maternal separation stress on dental enamel formation in a murine experimental model. PLoS One, v. 19, n. 12, p. 11-pg., 2024-12-19. (23/12014-8)

LEME, ROBERTA DUARTE; MARANON-VASQUEZ, GUIDO ARTEMIO; GONCALVES, JULIANA DE LIMA; DE CARVALHO, FABRICIO KITAZONO; DE QUEIROZ, ALEXANDRA MUSSOLINO; DE PAULA-SILVA, FRANCISCO WANDERLEY GARCIA. Effect of prenatal alcohol consumption on dental enamel formation in offspring-An animal study protocol. PLoS One, v. 20, n. 2, p. 12-pg., 2025-02-14. (23/12014-8)