Therapeutic, pharmacokinetic and pharmacodynamic profile of the oligopeptides derived from the snake venom B. Jararaca in the Parkinson's disease model in Zebrafish

• Grant number: 24/02247-8
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2024
• End date: June 30, 2026
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Agreement: CNPq
• Principal Investigator: Carlos Alberto da Silva
• Grantee: Carlos Alberto da Silva
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated research grant: 23/03608-1 - Bioprospection of neuroprotective peptides from snake venoms in vitro and in vivo experimental models for the study of neurodegenerative diseases, AP.R
• Associated scholarship(s): 24/10831-1 - Therapeutic, pharmacokinetic and pharmacodynamic profile of the oligopeptides derived from the snake venom B. Jararaca in the Parkinson's disease model in Zebrafish, BP.JD

Abstract

Neuroprotection mediated by proline-rich oligopeptides (PROs), derived from Bothrops jararaca snake venom, has been reported when different neuronal cell cultures are pre-treated with PROs and then exposed to oxidative stress. The neuroprotection of PRO-10c (