Stress-Induced Dysbiosis, Vagus Nerve Modulation, and Inflammation in Leaky Gut

• Grant number: 24/09233-2
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2025
• End date: December 31, 2026
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Carolina Demarchi Munhoz
• Grantee: Carolina Demarchi Munhoz
• Principal researcher abroad: Ivan Eid Tavares de Araújo
• Institution abroad: Max-Planck Institute For Biological Cybernetics, Germany
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 21/04077-4 - The role of astrocytic GPER in neuroprotection after transient focal cerebral ischemia: from angiogenesis to functional improvement, AP.R

Abstract

Leaky gut syndrome, characterized by increased intestinal permeability, has been linked to a myriad of health issues, including autoimmune diseases, metabolic disorders, and neurological conditions. Emerging evidence suggests that stress-induced dysbiosis, alterations in the composition of the gut microbiota, plays a crucial role in exacerbating gut permeability. However, the precise mechanisms underlying this phenomenon remain poorly understood. Furthermore, recent studies have implicated the vagus nerve, a key component of the parasympathetic nervous system, in the modulation of intestinal function. However, it is not yet completely clear how this nerve correlates with the inflammatory process triggered by changes in the microbiota as a result of stress, as well as its therapeutic potential in the prevention of leaky gut. (AU)