Grant number: | 24/07690-7 |
Support Opportunities: | Regular Research Grants |
Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
Principal Investigator: | Vania dos Santos Nunes Nogueira |
Grantee: | Vania dos Santos Nunes Nogueira |
Host Institution: | Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
Associated researchers: | Andrea Glezer ; Cesar Luiz Boguszewski |
Abstract
INTRODUCTION: Motherhood is idealized as a central milestone in the lives of many women, who see it as an opportunity to influence the next generation, a tangible legacy of their beliefs and values. Although pituitary adenomas are associated with decreased fertility, women affected by this type of tumor can become pregnant. While pregnancy may be a desired outcome for women with pituitary adenoma, there is concern about the adenoma negatively influencing pregnancy, as well as pregnancy negatively interfering in the natural history of pituitary adenomas. OBJECTIVE: To evaluate the association between pituitary tumors (functioning or not) and pregnancy in terms of disease control and newborn/maternal outcomes. METHODS: We have performed systematic reviews according to Joanna Briggs Institute methodology for systematic reviews of etiology and risk. We have included studies with pregnant women diagnosed with pituitary tumors before or during the first trimester of pregnancy. We have considered cohort and case series. Maternal outcomes will be overall frequency of control of pituitary tumor (Acromegaly, Prolactinoma, Cushing's disease and clinically non-functioning adenoma), preterm birth, gestational diabetes, hypertension, and miscarriage. Newborn outcomes will be perinatal mortality, congenital malformation, low birthweight, low for gestational age. General and adaptive search strategies have been created for the Embase, Medline, LILACS, and CENTRAL databases. Two independent reviewers will assess eligibility of the studies, extract data, and evaluate their risk of bias. For dichotomous data, effect estimates will be calculated using relative risk with 95% confidence intervals (CIs). We will perform proportional meta-analyses using Stata software, version 18, metaprop_one command. CONCLUSION: We hope that the results of this review can help the can outline the potential adverse maternal-fetal outcomes related to pregnancy in the presence of a pituitary adenoma, and from this guide clinical and counseling practices in women who wish to become pregnant in the presence of a pituitary adenoma. PROSPERO registration numbers: CRD42021283757, CRD42020151416 (AU)
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