Peptides and peptidases: biological activities in infectious diseases and cancer

• Grant number: 06/50634-2
• Support Opportunities: Research Projects - Thematic Grants
• Start date: September 01, 2006
• End date: December 31, 2010
• Field of knowledge: Biological Sciences - Biochemistry
• Principal Investigator: Luiz Rodolpho Raja Gabaglia Travassos
• Grantee: Luiz Rodolpho Raja Gabaglia Travassos
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated scholarship(s): 07/04428-4 - Lysosomal cysteine peptidases in pathologic process, BP.PD

Abstract

Peptides and peptidases are involved in such a way in the functioning of cells and of multi-cell organisms that practically the entire biological system or experimental model of some form uses substrates, mediators, inhibitors, antibiotics or antigens of peptidic nature as well as regulatory enzymes, which degrade, generate or chaperone peptides. The different biological activities of peptides and peptidases are always interlinked representing decisive steps in a variety of fundamental events in biology and medicine. The project involved several lines which contemplate the synthesis of peptides derivates and inhibitors, the use of peptides in experiences of immunoprotection, of antimicrobial and antitumoral cytoxicity, of regulation of immune responses. In the field of peptidases, the lines are concentrated on endooligopeptidases of tumor cells, fungi and bacteria. Substrates and serino-, cysteine- inhibitors, and metallopeptidases and catalyst mechanism are other lines focusing on kallikrein, catepsines, NEP, PHEX, ECA. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BORIN SCUTTI, JORGE A.; MATSUO, ALISSON LEONARDO; PEREIRA, FELIPE VALENCA; MASSAOKA, MARIANA HIROMI; FIGUEIREDO, CARLOS ROGERIO; MOREIRA, DAYSON FRIACA; BELIZARIO, JOSE ERNESTO; TRAVASSOS, LUIZ R.. Role of SOCS-1 Gene on Melanoma Cell Growth and Tumor Development. TRANSLATIONAL ONCOLOGY, v. 4, n. 2, p. 101-109, APR 2011. (06/50634-2)

ARRUDA, DENISE C.; SANTOS, LUANA C. P.; MELO, FILIPE M.; PEREIRA, FELIPE V.; FIGUEIREDO, CARLOS R.; MATSUO, ALISSON L.; MORTARA, RENATO A.; JULIANO, MARIA A.; RODRIGUES, ELAINE G.; DOBROFF, ANDREY S.; et al. beta-Actin-binding Complementarity-determining Region 2 of Variable Heavy Chain from Monoclonal Antibody C7 Induces Apoptosis in Several Human Tumor Cells and Is Protective against Metastatic Melanoma. Journal of Biological Chemistry, v. 287, n. 18, p. 14912-14922, APR 27 2012. (06/50634-2, 10/51423-0)

DA SILVA, MARCELO BARBOSA; THOMAZ, LUCIANA; MARQUES, ALEXANDRE FERREIRA; SVIDZINSKI, ARTUR E.; NOSANCHUK, JOSH D.; CASADEVALL, ARTURO; TRAVASSOS, LUIZ R.; TABORDA, CARLOS P.. Resistance of melanized yeast cells of Paracoccidioides brasiliensis to antimicrobial oxidants and inhibition of phagocytosis using carbohydrates and monoclonal antibody to CD18. Memórias do Instituto Oswaldo Cruz, v. 104, n. 4, p. 644-648, JUL 2009. (06/50634-2, 07/07588-2, 05/02776-0)

MARQUES, ALEXANDRE F.; DA SILVA, MARCELO B.; JULIANO, MARIA A. P.; MUNHOZ, JULIAN E.; TRAVASSOS, LUIZ R.; TABORDA, CARLOS P.. Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of Paracoccidioides brasiliensis. Microbes and Infection, v. 10, n. 12-13, p. 1251-1258, OCT 2008. (06/50634-2, 07/07588-2)

RITTNER, GLAUCE M. G.; MUNOZ, JULIAN E.; MARQUES, ALEXANDRE F.; NOSANCHUK, JOSHUA D.; TABORDA, CARLOS P.; TRAVASSOS, LUIZ R.. Therapeutic DNA Vaccine Encoding Peptide P10 against Experimental Paracoccidioidomycosis. PLoS Neglected Tropical Diseases, v. 6, n. 2, p. e1519, 2012. (06/50634-2, 07/07588-2, 09/15823-7)

MARCHI, L. H. L.; PASCHOALIN, T.; TRAVASSOS, L. R.; RODRIGUES, E. G.. Gene therapy with interleukin-10 receptor and interleukin-12 induces a protective interferon-gamma-dependent response against B16F10-Nex2 melanoma. Cancer Gene Therapy, v. 18, n. 2, p. 110-122, FEB 2011. (06/50634-2)

PRADO, MARLI; DA SILVA, MARCELO BARBOSA; LAURENTI, RUY; TRAVASSOS, LUIZ R.; TABORDA, CARLOS P.. Mortality due to systemic mycoses as a primary cause of death or in association with AIDS in Brazil: a review from 1996 to 2006. Memórias do Instituto Oswaldo Cruz, v. 104, n. 3, p. 513-521, MAY 2009. (06/50634-2, 07/07588-2, 05/02776-0)

POLONELLI, LUCIANO; PONTON, JOSE; ELGUEZABAL, NATALIA; DOLORES MORAGUES, MARIA; CASOLI, CLAUDIO; PILOTTI, ELISABETTA; RONZI, PAOLA; DOBROFF, ANDREY S.; RODRIGUES, ELAINE G.; JULIANO, MARIA A.; et al. Antibody Complementarity-Determining Regions (CDRs) Can Display Differential Antimicrobial, Antiviral and Antitumor Activities. PLoS One, v. 3, n. 6, JUN 11 2008. (06/50634-2)