Deciphering the GPCRome that regulates energy metabolism

• Grant number: 24/09790-9
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2024
• End date: September 30, 2026
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Luiz Osório Silveira Leiria
• Grantee: Luiz Osório Silveira Leiria
• Principal researcher abroad: Zachary Gerhart-Hines
• Institution abroad: University of Copenhagen, Denmark
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 23/13695-9 - Investigation on the pharmacological aspects underlying the antidiabetic effects of a thromboxane receptor (TP) antagonist, AP.R

Abstract

This application aims to consolidate a collaboration between two research groups with overlapping interests and synergistic experimental competences. Our groups are located at the University of São Paulo, Brazil, and at the University of Copenhagen, Denmark. Here, we propose a plan of joint activities including visits and exchange of faculty staff and PhD students. These exchanges will allow us to create and strengthen collaboration for ongoing projects, provide training to graduate students and postdoc fellows through seminars and workshops, and seed new collaborative projects that will potentially result in joint grant applications. The SPRINT grant application is an opportunity for us to establish a long-term alliance that will lead to an advance in our understanding on the regulation of thermogenesis by lipids, metabolites, and their G-protein coupled receptors (GPCRs). (AU)