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Role of hypothalamic S6Ks in metabolic regulation

Grant number: 18/07018-6
Support type:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): August 01, 2018
Effective date (End): December 31, 2018
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Fernando Moreira Simabuco
Grantee:Mariana Rosolen Tavares
Supervisor abroad: Carol Fuzeti Elias
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Local de pesquisa : University of Michigan, United States  
Associated to the scholarship:15/24475-3 - Modulation of expression of S6Ks in the central nervous system and its effects in obesity, BP.DD

Abstract

Obesity has been considered a worldwide epidemic. WHO data are categorical in assert that obesity is responsible for a number of pathologies development, including type II diabetes, cardiovascular disease, stroke, dyslipidemia, osteoarthritis and some cancers. Therefore, there is a great demand for a better understanding of biochemical and metabolic processes related to obesity. The mTOR protein pathway has been associated to the control of energy balance acting as a sensor of available nutrients and as a signal for the energy expenditure or energy storage. The present research project aims to study the different S6Ks proteins, known as effectors of the mTOR directed response, in the central nervous system (CNS) and their consequences for the energetic homeostasis. The project's proposal is to use a Cre-dependent adeno-associated viral (AAV) system to overexpress the S6Ks isoforms (p70-S6K1 and p54-S6K2) in adult male POMC-Cre mice, available at the University of Michigan, under the supervision Dr. Carol Elias. The S6Ks overexpression will be directed to specific neurons that express POMC neuropeptides in the hypothalamus, allowing the specific analysis of their effects. Regarding problems involving obesity, its associated diseases and the mTOR/S6Ks pathway's role in metabolism control, it is expected that the development of the present research project may bring forward greater understanding of the biochemical and metabolic processes behind these conditions, in addition to the possibility of developing of more effective and safer treatments.