Revolutionizing the tissue engineering realm: patient-specific living implants at the speed of light

• Grant number: 24/08578-6
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2025
• End date: December 31, 2027
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Luiz Henrique Catalani
• Grantee: Luiz Henrique Catalani
• Principal researcher abroad: Sandra Van Vlierberghe
• Institution abroad: Ghent University (UGent), Belgium
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Quinten Thijssen

Abstract

In the field of tissue engineering, 3D printing has received increasing attention due to its ability to create high-resolution, patient-specific implants. These implants are essential for achieving a perfect fit to the existing defect and guaranteeing the best possible aesthetic result. Over the last decade, the application of light-mediated 3D printing techniques, such as digital light processing (DLP), two-photon polymerization (2PP), and, more recently, volumetric additive manufacturing (VAM), has seen intense growth. These techniques make it possible to manufacture complex constructs that mimic biological tissues with high precision and timely speed. In all cases, a photosensitive ink is required. The main aim of the project is to chemically devise a hydrogel-based ink that is versatile and interacts with cells for use in VAM, enabling the 3D printing of patient-specific implants that stimulate tissue growth. This innovative hydrogel ink will provide a multifunctional platform that manages, (i) unprecedented mechanical properties, (ii) non-destructive imaging by monitoring the status of the implant, (iii) antioxidant and pro-angiogenic properties, (iv) adjustable biodegradability. The successful completion of this project is expected to significantly advance the field of tissue engineering by introducing a revolutionary materials platform that combines rapid manufacturing, superior mechanical properties and great functional versatility. The development of cell-interactive photo-crosslinkable resins and the ability to manufacture highly precise, patient-specific implants in seconds will provide unprecedented opportunities for personalized medicine. (AU)