"EMU: Acquisition of 3D bioprinting, laser cutting and fluorescence microscope for implementation of organs-on-a-chip and organoids facility"

• Grant number: 23/17448-6
• Support Opportunities: Research Infrastructure Program - Small Medium Sized
• Start date: September 01, 2024
• End date: August 31, 2027
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Rondinelli Donizetti Herculano
• Grantee: Rondinelli Donizetti Herculano
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated researchers: Antonio Carlos Guastaldi

Abstract

Research Centers, Universities, Pharmaceutical Industries face ethical and regulatory issues for animal experimentation, making it necessary to find sustainable and effective solutions for testing bioproducts. In this way, microfluidic systems (organ-on-a-chip technologies) are innovative enabling platforms for organ modeling and drug screening; being able to mimic complex tissue architectures and various organ-level interactions. During my stay at the Terasaki Institute (Los Angeles), University of California at Los Angeles and California State University Northridge I developed a skin-on-a-chip and wound-on-a-chip device to replace animal testing. Therefore, I have experience to develop organs-on-a-chip for testing dressings, drugs and bioproducts as this system uses skin-on-a-chip with adaptations. The Bioengineering and Biomaterials Group at FCF/UNESP, which I coordinate, develops several dressings for dermal regeneration and developing this more real and complex system will facilitate the development of various natural and/or synthetic dressings. Furthermore, the entire São Paulo community (researchers and teachers) will have an "Organs-on-a-chip facility" to test their bioproducts, biomaterials and bioactive compounds. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE BARROS, NATAN ROBERTO; CHAGAS, ANA LAURA DESTRO; FORSTER, SAMUEL; BRASIL, GIOVANA SANT'ANA PEGORIN; RIBEIRO, GERALDO MONTEIRO; OLIVATO, ORESTES PEREIRA; RAMALHO, LEANDRA NAIRA ZAMBELLI; GUERRA, NAYRIM BRIZUELA; MUSSAGY, CASSAMO USSEMANE; FLORIANO, JULIANA FERREIRA; et al. Novel highly flexible collagen-loaded latex dressing to treat diabetic foot ulcer: A pilot clinical trial. International Journal of Biological Macromolecules, v. 308, p. 20-pg., 2025-05-01. (17/19603-8, 11/17411-8, 23/17448-6, 17/02518-8, 18/07342-8)

PIAZZA, RODOLFO DEBONE; PINTO, GABRIEL CARDOSO; VISONA, VITOR MATTOS; HERCULANO, RONDINELLI DONIZETTI; SANTOS, LINDOMAR SOARES DOS; PRIMO, FERNANDO LUCAS; FERNANDES, MARIZA AIRES; DE SOUZA, FRANCISLEY A.; MARQUES, RODRIGO FERNANDO COSTA; GUASTALDI, ANTONIO CARLOS. Size-controlled hydroxyapatite particle nucleation in natural rubber latex membranes. Materials Chemistry and Physics, v. 337, p. 11-pg., 2025-03-01. (21/04707-8, 23/17448-6)

SASAKI, JOSANA CARLA DA SILVA; SU, YANJIN; SPINOSA, WILMA APARECIDA; LOPES FILHO, PAULO EDUARDO DE LIMA; BURD, BETINA SAYEG; SCONTRI, MATEUS; TANAKA, JEAN LUCAS; GONCALVES, ROGERIO PENNA; BRIDI, FELISBINO BIANCA; DOS SANTOS, LINDOMAR SOARES; et al. Eco-sustainable, edible, biodegradable and antioxidant pectin and bacterial cellulose films loaded with coconut oil for strawberry preservation. International Journal of Biological Macromolecules, v. 308, p. 17-pg., 2025-05-01. (15/11759-3, 23/17448-6)

MUSSAGY, CASSAMO U.; DIAS, JULIA N.; CAICEDO-PAZ, ANGIE V.; GINI, ANA L. R.; SCARIM, CAUE B.; TROPEA, ALESSIA; LA TELLA, ROBERTA; MONDELLO, LUIGI; LOPES-FILHO, PAULO E. L.; TANAKA, JEAN L.; et al. Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages. International Journal of Biological Macromolecules, v. 305, p. 17-pg., 2025-05-01. (21/06686-8, 15/11759-3, 23/17448-6)