Use of Aspirin for Preeclampsia Prevention in Pregnant Women with Chronic Hypertension: A Retrospective Analysis of a Tertiary Hospital in Brazil

• Grant number: 25/13946-7
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2025
• End date: September 30, 2026
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Ricardo de Carvalho Cavalli
• Grantee: Ricardo de Carvalho Cavalli
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto
• Associated research grant: 21/12010-7 - Endothelial dysfunction in hypertensive disorders of pregnancy, AP.TEM
• Associated scholarship(s): 25/22181-4 - Aspirin Use for Preeclampsia Prevention in Pregnant Women with Chronic Hypertension: A Retrospective Analysis from a Tertiary Hospital in Brazil, BP.IC

Abstract

Preeclampsia is a gestational complication characterized by hypertension, target-organ damage, proteinuria, and edema, with significant implications for maternal-fetal health. Pregnant women with chronic hypertension are at increased risk of developing superimposed preeclampsia, a condition associated with high rates of morbidity and mortality. The prophylactic use of low-dose aspirin (50 to 150 mg/day) has been widely recommended as a preventive strategy, although its efficacy, especially in pregnant women with chronic hypertension, still lacks consistent evidence. This study aims to evaluate the incidence of superimposed preeclampsia in pregnant women with chronic hypertension receiving prophylactic aspirin, in a tertiary healthcare unit in Brazil. The research aims to provide data that can contribute to the definition of more effective preventive strategies for this population, to improve maternal and neonatal outcomes, as well as fostering the development of new therapeutic approaches for the management of hypertensive disorders in pregnancy. (AU)