Evaluation of liquid-liquid extraction in flow systems using magnetic liquids

• Grant number: 25/19495-7
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2026
• End date: January 31, 2027
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Diogo Librandi da Rocha
• Grantee: Diogo Librandi da Rocha
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Santo André , SP, Brazil
• City of the host institution: Santo André
• Associated research grant: 24/06616-8 - Exploiting magnetic properties for the development of modern extraction strategies e construction of sensors for analytical applications, AP.R

Abstract

Dispersive liquid-liquid microextraction (DLLME) is usually a fast and efficient strategy for sample preparation. The automation of this process has been achieved in flow analysis systems using solenoid micro-pumps. However, the analytical throughput and precision can be improved with faster and more efficient phase separation. Magnetic dispersive liquid-liquid microextraction (MDLLME) simplifies the phase separation. A magnetic liquid is employed as the extractor, being retained inside the tube with the aid of an external magnet, which allows the aqueous phase to be discarded without centrifugation. Although MDLLME has been applied in several fields, it has not yet been explored for extractions in flow analysis systems. In this project, magnetic liquids (ionic and/or eutectic solvents) will be evaluated for the automation of MDLLME in a flow system. The sample and the organic phase will be mixed in-line for extraction. The phases will be separated by retaining the magnetic solvent through an electromagnet placed outside the system and coupled to a 3D-printed spectrophotometric cell. To evaluate this strategy, iodine will be extracted into the organic phase from an aqueous triiodide solution. Parameters will be optimized to achieve maximum extraction efficiency and analytical frequency. The results will be important for future applications using this strategy for in-line sample preparation. Subsequently, the procedure will be applied to the analysis of pharmaceutical samples (Lugol solutions). (AU)