Flow-based analytical procedures exploiting on-line decompositions and extractions for fractionation and total determinations

• Grant number: 15/12172-6
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2015
• End date: February 28, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Diogo Librandi da Rocha
• Grantee: Diogo Librandi da Rocha
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil

Abstract

Flow-based sample preparation is less susceptible to analyte loss and contamination. The sample processing is highly reproducible, allowing analytical applications of incomplete decompositions and extractions. In this project, strategies for on-line decompositions and extractions will be evaluated employing UV and microwave irradiation and liquid-liquid and solid-liquid interactions. The flow systems will be based on continuous reagent addition or multicommutation. Decompositions and pre-concentrations will be coupled for continuous analysis. The aim is the development of analytical procedures for phosphorus fractionation in natural waters and vegetable materials. On-line solid-liquid extraction will be evaluated, as well as new strategies for detection of rich-phase obtained from cloud point extraction. Batch sample microdigestion (including with suspensions) will be explored to enrich the fractionation studies in vegetable materials. Fast analytical procedures for pharmaceuticals determinations will be developed based on the quantification of heteroatoms (e.g. P, S, N, F) after on-line heterogeneous photoconversion using new strategies for the immobilization of semiconductors. The procedures will be employed for dynamical dissolution studies of pharmaceutical preparations. The analytical features will be estimated and the results of the analysis of real samples will be compared to the ones obtained with reference and/or alternative procedures in the literature. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MACEDO, V, CAIO C.; MANCINI, RODRIGO S. N.; ARAKAKI, CAROLINA Y.; ROCHA, DIOGO L.. In-Line Incomplete Solid-Liquid Extraction for Spectrophotometric Determination of Soluble Inorganic Phosphorus in Plants and Foods. Journal of the Brazilian Chemical Society, v. 29, n. 11, p. 2334-2341, NOV 2018. (15/12172-6)

MANCINI, RODRIGO S. N.; DE JESUS, FERNANDO P.; DA ROCHA, ALESSANDRA M.; CARVALHO, ALEXANDRE Z.; ROCHA, DIOGO L.. An automated flow system for in-line extraction of proteins and separation of jacalin using a low-cost stationary phase. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1130, NOV 1 2019. (15/12172-6)

MACEDO, CAIO C., V; MANCINI, RODRIGO S. N.; ARAKAKI, CAROLINA Y.; ROCHA, DIOGO L.. In-Line Incomplete Solid-Liquid Extraction for Spectrophotometric Determination of Soluble Inorganic Phosphorus in Plants and Foods. Journal of the Brazilian Chemical Society, v. 29, n. 11, p. 8-pg., 2018-11-01. (15/12172-6)

REIS, FELIPE EDUARDO; MARINGOLO, VIVIAN; ROCHA, DIOGO LIBRANDI. Fast and Simple Spectrophotometric Procedure for Determination of TiO2 in Paint Samples. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 6, n. 22, SI, p. 52-59, JAN-MAR 2019. (15/12172-6, 18/05559-0)

MARINGOLO, VIVIAN; ALEIXO, FERNANDA CAROLINE; CARVALHO, ALEXANDRE ZATKOVSKIS; ROCHA, DIOGO LIBRANDI. Exploitation of flow-based procedures for reagentless hydrochlorothiazide determination and accelerated degradation studies of pharmaceutical preparations. ANALYTICAL METHODS, v. 13, n. 4, p. 497-503, JAN 28 2021. (15/11523-0, 15/12172-6)

MARINGOLO, VIVIAN; CARVALHO, ALEXANDRE ZATKOVSKIS; ROCHA, DIOGO LIBRANDI. A novel online dispersive liquid-liquid microextraction for the spectrophotometric determination of free glycerol in biodiesel. ANALYTICAL METHODS, v. 15, n. 24, p. 8-pg., 2023-05-19. (15/12172-6, 18/05559-0)

COSTA, NAIARA S.; MARINGOLO, VIVIAN; BRASIL, MARCOS A. S.; ROCHA, DIOGO L.; MELCHERT, WANESSA R.. Online sample preparation of milk samples for spectrophotometric determination of formaldehyde. Journal of Food Composition and Analysis, v. 119, p. 7-pg., 2023-03-10. (18/24029-1, 15/12172-6)

REIS, FELIPE EDUARDO; MARINGOLO, VIVIAN; ROCHA, DIOGO LIBRANDI. Fast and Simple Spectrophotometric Procedure for Determination of TiO2 in Paint Samples. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 6, n. 22, p. 8-pg., 2019-01-01. (15/12172-6, 18/05559-0)