Alternative electron transfer pathways, respiratory supercomplexes and mitochondrial morphology

• Grant number: 25/23820-0
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2026
• End date: February 28, 2027
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Marcos Túlio de Oliveira
• Grantee: Marcos Túlio de Oliveira
• Principal researcher abroad: Mike Gerards
• Institution abroad: Maastricht University ,
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto
• Associated research grant: 21/06711-2 - Modulation of tissue growth and biomass accumulation by the mitochondrial alternative oxidase, AP.JP2

Abstract

Mitochondria rely on respiratory complexes and supercomplexes (SCs) to generate usable cellular energy and to maintain their shape. The alternative oxidase (AOX), found in tunicates but naturally absent in vertebrates and insects, mitigates mitochondrial dysfunction, potentially altering mitochondrial structure and function. Using diverse cells and animal models, we will integrate advanced microscopy and biochemical techniques to study the impact of AOX on mitochondrial ultrastructure and SC organization. Our findings will enhance understanding of mitochondrial adaptability, with implications for AOX-based therapies for mitochondrial diseases, ensuring effectiveness while minimizing side effects. This pioneering study bridges mitochondrial biology, evolution, and biomedical applications. (AU)